Does the fatty acid DHA modulates the dopamine receptor 2 (DR2)?
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DHA has been shown to modulate the oligomerization of dopamine receptor 2 (DR2) . However, a study found that D2-like receptor initiated signaling does not involve DHA as a second messenger . Another study demonstrated that DHA regulates dopamine D2 receptor functions through heart-type fatty acid binding protein (H-FABP) in the brain . Additionally, a diet-induced loss of brain DHA content was found to decrease the density of ventral striatal D2-like receptors . Therefore, while DHA may have an effect on DR2 through its role in receptor oligomerization and H-FABP-mediated regulation, it does not appear to directly modulate DR2 signaling as a second messenger.
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01 Jan 2021 2 Citations | The given text does not provide any information about the modulation of the dopamine receptor 2 (DR2) by the fatty acid DHA. |
| Yes, the study found that a diet-induced decrease in brain DHA content resulted in a decreased density of ventral striatal D2-like receptors in female rats. | |
Open access•Journal Article 3 Citations | Yes, the fatty acid DHA can modulate the dopamine receptor 2 (DR2) through the heart-type fatty acid binding protein (H-FABP). |
| No, the study found that D2-like receptor activation does not involve DHA as a second messenger. | |
| Yes, the fatty acid DHA modulates the oligomerisation kinetics of dopamine receptor 2 (DR2). |
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