R
Ramon Guixà-González
Researcher at Paul Scherrer Institute
Publications - 37
Citations - 1107
Ramon Guixà-González is an academic researcher from Paul Scherrer Institute. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 13, co-authored 33 publications receiving 687 citations. Previous affiliations of Ramon Guixà-González include Charité & Pompeu Fabra University.
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Journal ArticleDOI
MEMBPLUGIN: studying membrane complexity in VMD.
Ramon Guixà-González,Ismael Rodríguez-Espigares,Juan Manuel Ramírez-Anguita,Pau Carrió-Gaspar,Hector Martinez-Seara,Toni Giorgino,Jana Selent +6 more
TL;DR: MEMBPLUGIN is a plugin for the Visual Molecular Dynamics package that provides algorithms to measure a host of essential biophysical properties in simulated membranes and is accessible both through a user-friendly graphical interface and as command-line procedures to be invoked in analysis scripts.
Journal ArticleDOI
Membrane cholesterol access into a G-protein-coupled receptor.
Ramon Guixà-González,José Luis Albasanz,Ismael Rodríguez-Espigares,Manuel Pastor,Ferran Sanz,Maria Marti-Solano,Moutusi Manna,Hector Martinez-Seara,Hector Martinez-Seara,Peter W. Hildebrand,Mairena Martín,Jana Selent +11 more
TL;DR: Overall, it is shown that cholesterol's impact on A2AR-binding affinity goes beyond pure allosteric modulation and unveils a new interaction mode between cholesterol and the A2 AR that could potentially apply to other GPCRs.
Journal ArticleDOI
Structural Insights into the Process of GPCR-G Protein Complex Formation.
Xiangyu Liu,Xinyu Xu,Daniel Hilger,Philipp Aschauer,Johanna K. S. Tiemann,Yang Du,Hongtao Liu,Kunio Hirata,Xiaoou Sun,Ramon Guixà-González,Jesper Mosolff Mathiesen,Peter W. Hildebrand,Brian K. Kobilka,Brian K. Kobilka +13 more
TL;DR: In this article, the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state.
Journal ArticleDOI
Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors
Ramon Guixà-González,Matti Javanainen,Maricel Gómez-Soler,Begoña Cordobilla,Joan Carles Domingo,Ferran Sanz,Manuel Pastor,Francisco Ciruela,Francisco Ciruela,Hector Martinez-Seara,Jana Selent +10 more
TL;DR: It is revealed for the first time that membrane ω-3 PUFAs play a key role in GPCR oligomerisation kinetics, which may have important implications for neuropsychiatric conditions like schizophrenia or Parkinson’s disease.
Journal ArticleDOI
GPCRmd uncovers the dynamics of the 3D-GPCRome
Ismael Rodríguez-Espigares,Mariona Torrens-Fontanals,Johanna K. S. Tiemann,Johanna K. S. Tiemann,David Aranda-García,Juan Manuel Ramírez-Anguita,Tomasz Maciej Stepniewski,Nathalie Worp,Alejandro Varela-Rial,Adrián Morales-Pastor,Brian Medel Lacruz,Gáspár Pándy-Szekeres,Eduardo Mayol,Toni Giorgino,Toni Giorgino,Jens Carlsson,Xavier Deupi,Slawomir Filipek,Marta Filizola,José Carlos Gómez-Tamayo,Angel Gonzalez,Hugo Gutiérrez-de-Terán,Mireia Jiménez-Rosés,Willem Jespers,Jon Kapla,George Khelashvili,Peter Kolb,Dorota Latek,Maria Marti-Solano,Maria Marti-Solano,Pierre Matricon,Minos-Timotheos Matsoukas,Minos-Timotheos Matsoukas,Przemyslaw Miszta,Mireia Olivella,Laura Pérez-Benito,Davide Provasi,Santiago Ríos,Iván Rodríguez-Torrecillas,Jessica Sallander,Agnieszka Sztyler,Silvana Vasile,Harel Weinstein,Ulrich Zachariae,Peter W. Hildebrand,Peter W. Hildebrand,Gianni De Fabritiis,Ferran Sanz,David E. Gloriam,Arnau Cordomí,Ramon Guixà-González,Jana Selent +51 more
TL;DR: GPCRmd is an online platform that incorporates web-based visualization capabilities as well as a comprehensive and user-friendly analysis toolbox that allows scientists from different disciplines to visualize, analyze and share GPCR MD data.