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Effects of arsenic on humans nervous system system?

Arsenic contamination of groundwater

Arsenic toxicity

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Arsenic exposure poses significant risks to the human nervous system. Chronic exposure to arsenic, primarily through sources like contaminated groundwater, can lead to developmental neurotoxicity, cognitive impairment, neurobehavioral effects, and neurodegenerative disorders. Mechanisms of arsenic-induced neurotoxicity include oxidative stress, apoptosis, DNA damage, neurotransmitter disruption, and epigenetic changes. Long-term exposure may result in cognitive dysfunction, cardiovascular issues, peripheral vascular disease, and various neurological disorders. Arsenic toxicity can affect both the central and peripheral nervous systems, with symptoms ranging from sensory and motor nerve damage to central nervous system impairment. Mitigating arsenic's detrimental effects involves understanding its toxicology, implementing strategies for management, and potentially considering chelation therapy for acute toxicity. Preventative measures like using safe water sources are crucial in reducing further exposure risks.

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Open access•Journal Article•DOI Arsenic Neurotoxicity in Humans Hitoshi Mochizuki 11 Jul 2019-International Journal of Molecular Sciences 101 Citations	Arsenic neurotoxicity in humans primarily affects peripheral nerves, causing axonal degeneration in sensory fibers with minimal impact on motor fibers. Central nervous system impairment is severe in infants.
Journal Article•DOI Effects of arsenic-induced toxicosis (Arsenicosis) on human health and its prevention Samya Mairaj, Richa Nagar, Fozia Rehman, Tanu Jindal - Show less +3 more 15 Feb 2023-Research Journal of Chemistry and Environment	Arsenic-induced toxicosis can lead to neurological disorders in humans, including cognitive dysfunction and neurological diseases, due to chronic exposure to arsenic pollution.
Book Chapter•DOI Effects of Arsenic: Neurological and Cellular Perspective Anushree, Jawaid Ahsan - Show less +1 more 01 Jan 2021	Arsenic induces neurotoxicity leading to cognitive impairment, neurochemical alterations, and neurodevelopmental changes. It can affect cholinergic and dopaminergic systems, potentially causing neurological and neurodegenerative disorders in humans.
Open access•Journal Article•DOI Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions. Manisha Thakur, Mahesh Rachamalla, Som Niyogi, Ashok Kumar Datusalia, Swaran J.S. Flora - Show less +4 more 17 Sep 2021-International Journal of Molecular Sciences 43 Citations	Arsenic exposure impacts human nervous system through cytotoxicity, genotoxicity, and neurobehavioral effects, leading to neuronal dysfunctions. Understanding molecular mechanisms is crucial for mitigation strategies.
Book Chapter•DOI Developmental arsenic exposure impacts fetal programming of the nervous system 01 Jan 2023	Developmental arsenic exposure impacts fetal programming of the nervous system, inducing oxidative stress, apoptosis, DNA damage, neurotransmitter disruption, and epigenetic changes, potentially affecting long-term neurodevelopment in humans.

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