How do genetic and environmental factors interact in the development of neurodegenerative diseases?
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Genetic and environmental factors play crucial roles in the development of neurodegenerative diseases. These diseases, such as Alzheimer's, Parkinson's, and ALS, arise from a complex interplay of genetic predisposition and environmental exposures. Research highlights that mitochondrial dysfunction, misfolded protein aggregation, and oxidative stress are common pathogenic pathways influenced by these factors. Studies emphasize the need to understand how genetic and environmental factors interact to modify disease risk, penetrance, and severity. In multifactorial diseases like neurodegenerative disorders, the mechanisms underlying gene-environment interactions are challenging to decipher but are crucial for effective disease management. Insights suggest that inflammation may serve as a unifying biological principle in destabilizing homeostasis and impacting disease progression, offering potential therapeutic targets.
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| Genetic variations in Alzheimer's and Parkinson's disease may induce inflammation, which can be exacerbated by environmental factors, suggesting neuroinflammation as a common mechanism in disease development. | |
3 Citations | Genetic and environmental factors interact in neurodegenerative diseases like Parkinson's, influencing disease risk and severity. The paper discusses their interplay and potential modifiers, emphasizing the need for further research. |
09 Aug 2022 | Genetic and environmental factors interact in neurodegenerative diseases, influencing disease risk and progression through pathways like mitochondrial dysfunction, protein aggregation, and oxidative stress, as outlined in the paper. |
| Genetic and environmental factors interact complexly in neurodegenerative diseases, impacting disease development. Molecular epidemiology helps identify high-risk genes, prognostic factors, and environmental exposures influencing disease susceptibility. |
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