scispace - formally typeset
Search or ask a question

Answers from top 8 papers

More filters
Papers (8)Insight
The safe upper single dose of retinol in oil or liver seems to be approximately 4-6 mg/kg body wt.
This method is fast, selective and highly sensitive for retinol.
These data make it likely that esterase 22 and β-glucuronidase act in concert in mobilizing retinol from retinol esters and retinoyl β-glucuronide.
It is suggested that cellular retinol-binding proteins are important for intracellular metabolism of retinol.
The CRBP-retinol complex appears to be the quantitatively major form of retinol in vivo, and may protect the promiscuous substrate from nonenzymatic degradation and/or non-specific enzymes.
The nucleotide sequence suggests a putative 16-aa signal peptide and shows all the aa residues that were previously identified as critical for the retinol binding pocket.
Retinol solubility was increased in presence of cyclodextrins while DSC analysis suggest that this inclusion agents are able to interact with retinol.
CRBP may participate in the entry of retinol into the cell.