How does anabasine regulate the expression of anti-inflammatory cytokines in the body?
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Anabasine, an alkaloid found in plants like tobacco and eggplant, has been shown to modulate anti-inflammatory responses through various mechanisms. Studies indicate that anabasine activates α-7n acetylcholine receptors, leading to a reduction in proinflammatory cytokines like TNF-α, IL-1β, and IL-6. Additionally, anabasine's full agonistic action on nicotinic acetylcholine receptors contributes to its anti-inflammatory properties, normalizing conditions like asthma and atopic dermatitis. In models of inflammatory bowel disease (IBD), anabasine has shown promise in reducing colitis symptoms by restoring global gene expression profiles and decreasing DSS-associated cytokines while increasing IL-10 levels. Furthermore, anabasine analogs have demonstrated potent anti-inflammatory effects in humans by inhibiting neutrophil infiltration and promoting the biosynthesis of pro-resolving lipid mediators.
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| Papers (5) | Insight |
|---|---|
| Anatabine reduces pro-inflammatory cytokines and increases IL-10 expression, promoting an anti-inflammatory response in the body, as shown in a DSS mouse model of colitis. | |
| Anabasine normalizes asthma, chest allergies, and atopic dermatitis by acting as a full agonist on al nicotinic acetylcholine receptors, which can regulate the expression of anti-inflammatory cytokines in the body. | |
53 Citations | Anabasum regulates anti-inflammatory cytokines by inhibiting LTB4, enhancing clearance of inflammatory stimuli, and triggering specialized pro-resolving lipid mediators like LXA4 and RvD1 in the body. |
Open access•Journal Article 1 Citations | Anabasine activates α-7n AChR, reducing proinflammatory cytokines (TNF-α, IL-1β, IL-6) in sepsis, leading to decreased mortality in mice, but its effect on anti-inflammatory cytokines is not addressed in the paper. |
| Anatabine activates NRF2 and MAPK signaling pathways, potentially regulating anti-inflammatory cytokine expression in the body, as shown in the study. |
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