How does mutation in gyrA affect resistance towards fluoroquinolone?
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Mutations in gyrA have been found to play a significant role in fluoroquinolone resistance . Different mutations in gyrA, such as Ser83Leu, Asp87Asn, and Ala93Gly/Glu, have been identified in various studies . These mutations have been associated with high levels of resistance to fluoroquinolones, including norfloxacin and ciprofloxacin . However, it has also been observed that certain gyrA mutations, such as Ser83Leu, can be present in sensitive strains . Molecular docking studies have shown that mutated gyrA proteins have lower binding energies with fluoroquinolones, leading to reduced efficacy of the drugs . Additionally, the presence of other mutations in gyrB has been found to contribute to fluoroquinolone resistance, both individually and through interactions with gyrA mutations . These findings highlight the complex nature of fluoroquinolone resistance and the importance of understanding the specific mutations in gyrA and gyrB for predicting resistance and selecting appropriate treatment options .
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64 Citations | Mutation in gyrA can lead to varying levels of resistance to fluoroquinolones, including ofloxacin and moxifloxacin. |
8 Citations | Mutations in gyrA can lead to resistance towards fluoroquinolones in Mycobacterium tuberculosis. |
15 Citations | The paper did not find any resistance-associated mutations in gyrA or gyrB in fluoroquinolone-resistant isolates of Mycobacterium avium complex and Mycobacterium abscessus complex. |
30 Citations | Mutation in gyrA can lead to increased resistance to fluoroquinolones, as observed in the study. |
6 Citations | Mutation in gyrA leads to fewer hydrogen bonds in the DNA gyrase-fluoroquinolone complex, resulting in low susceptibility of the ligand in inhibiting the mutant protein. |
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