A
Alexander Sloutsky
Researcher at University of Massachusetts Medical School
Publications - 54
Citations - 3166
Alexander Sloutsky is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 26, co-authored 54 publications receiving 2846 citations. Previous affiliations of Alexander Sloutsky include Harvard University & Varian Medical Systems.
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Journal ArticleDOI
Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis
Maha R. Farhat,B. Jesse Shapiro,Karen J. Kieser,Razvan Sultana,Karen R. Jacobson,Karen R. Jacobson,Thomas C. Victor,Robin M. Warren,Elizabeth M. Streicher,Alistair Calver,Alexander Sloutsky,Devinder Kaur,Jamie E. Posey,Bonnie B. Plikaytis,Marco R. Oggioni,Jennifer L. Gardy,James C. Johnston,Mabel Rodrigues,Patrick Tang,Midori Kato-Maeda,Mark L. Borowsky,Bhavana Muddukrishna,Barry N. Kreiswirth,Natalia Kurepina,James E. Galagan,Sebastien Gagneux,Sebastien Gagneux,Bruce W. Birren,Eric J. Rubin,Eric S. Lander,Pardis C. Sabeti,Megan Murray +31 more
TL;DR: Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin, and evidence of positive selection in an additional 39 genomic regions in resistant isolates was found.
Journal ArticleDOI
Comprehensive treatment of extensively drug-resistant tuberculosis.
Carole D. Mitnick,Sonya Shin,Kwonjune J. Seung,Michael Rich,Sidney Atwood,Jennifer Furin,Garrett M. Fitzmaurice,Felix A. Alcantara Viru,Sasha C. Appleton,Jaime Bayona,Cesar Bonilla,Katiuska Chalco,Sharon S Choi,Molly F. Franke,Hamish S. F. Fraser,Dalia Guerra,Rocío M. Hurtado,Darius Jazayeri,Keith Joseph,Karim Llaro,Lorena Mestanza,Joia S. Mukherjee,Maribel Muñoz,Eda Palacios,Epifanio Sánchez,Alexander Sloutsky,Mercedes C. Becerra +26 more
TL;DR: Extensively drug-resistant tuberculosis can be cured in HIV-negative patients through outpatient treatment, even in those who have received multiple prior courses of therapy for tuberculosis.
Journal ArticleDOI
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.
Caroline Allix-Béguec,Irena Arandjelovic,Lijun Bi,Patrick Beckert,Maryline Bonnet,Phelim Bradley,Andrea M. Cabibbe,Irving Cancino-Muñoz,Mark J. Caulfield,Angkana Chaiprasert,Daniela Maria Cirillo,David A. Clifton,Iñaki Comas,Derrick W. Crook,Maria Rosaria De Filippo,Han de Neeling,Roland Diel,Francis Drobniewski,Kiatichai Faksri,Maha R. Farhat,Joy Fleming,Philip W. Fowler,Tom Fowler,Qian Gao,Jennifer L. Gardy,Deborah Gascoyne-Binzi,Ana-Luiza Gibertoni-Cruz,Ana Gil-Brusola,Tanya Golubchik,Ximena Gonzalo,Louis Grandjean,Guangxue He,Jennifer L. Guthrie,Sarah Hoosdally,Martin Hunt,Zamin Iqbal,Nazir Ahmed Ismail,James C. Johnston,Faisal Masood Khanzada,Chiea Chuen Khor,Thomas Kohl,Clare Kong,Samuel Lipworth,Qingyun Liu,Gugu Maphalala,Elena Martinez,Vanessa Mathys,Matthias Merker,Paolo Miotto,Nerges Mistry,David Moore,Megan Murray,Stefan Niemann,Shaheed V. Omar,Rick T-H Ong,Tim E. A. Peto,James E. Posey,Therdsak Prammananan,Alexander S. Pym,Camilla Rodrigues,Mabel Rodrigues,Timothy C. Rodwell,Gian Maria Rossolini,Elisabeth Sánchez Padilla,Marco Schito,Xin Shen,Jay Shendure,Vitali Sintchenko,Alexander Sloutsky,E. Grace Smith,Matthew W. Snyder,Karine Soetaert,Angela M. Starks,Philip Supply,Prapat Suriyapol,Sabira Tahseen,Patrick Tang,Yik Ying Teo,Thuong N T Thuong,Guy E. Thwaites,Enrico Tortoli,Dick van Soolingen,A. Sarah Walker,Timothy M Walker,Mark H. Wilcox,Daniel J. Wilson,David H. Wyllie,Yang Yang,Hongtai Zhang,Yanlin Zhao,Baoli Zhu +90 more
TL;DR: Genotypic predictions of the susceptibility of M. tuberculosis to first‐line drugs were found to be correlated with phenotypic susceptibility to these drugs.
Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis
Maha R. Farhat,B. Jesse Shapiro,Karen J. Kieser,Razvan Sultana,Karen R. Jacobson,Karen R. Jacobson,Thomas C. Victor,Robin M. Warren,Elizabeth M. Streicher,Alistair Calver,Alexander Sloutsky,Devinder Kaur,Jamie E. Posey,Bonnie B. Plikaytis,Marco R. Oggioni,Jennifer L. Gardy,James C. Johnston,Mabel Rodrigues,Patrick Tang,Midori Kato-Maeda,Mark L. Borowsky,Bhavana Muddukrishna,Barry N. Kreiswirth,Natalia Kurepina,James E. Galagan,Sebastien Gagneux,Sebastien Gagneux,Bruce W. Birren,Eric J. Rubin,Eric S. Lander,Pardis C. Sabeti,Megan Murray +31 more
TL;DR: In this article, the authors identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains of M. tuberculosis and identified positive selection in 39 genomic regions in resistant isolates, encoding components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways.
Journal ArticleDOI
The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.
Jyothi Rengarajan,Christopher M. Sassetti,Vera Naroditskaya,Alexander Sloutsky,Barry R. Bloom,Eric J. Rubin +5 more
TL;DR: PAS acts in the folate pathway, and thyA mutations probably represent a mechanism of developing resistance not only to PAS but also to other drugs that target folate metabolism.