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How does TRIP12 interact with dcaf7?

Binding protein

Head and neck squamous-cell carcinoma

Skeletal muscle

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TRIP12 interacts with DCAF7 by mediating branched K11-linked ubiquitylation of FBW7, regulating its stability and affecting the abundance of SCFFBW7 substrates . Additionally, DCAF7, also known as WDR68, binds DYRK1A and DYRK1B, playing a crucial role in maintaining normal levels of these kinases . Furthermore, Trip12 is involved in the ubiquitination of Sox6, a transcription factor in muscle cells, leading to its polyubiquitination and subsequent degradation via the ubiquitin-proteasome system . These interactions highlight the diverse roles of TRIP12 in regulating the stability and activity of various proteins involved in critical cellular processes.

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Open access•Journal Article•DOI Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells Chung Il An, Edward A. Ganio, Nobuko Hagiwara - Show less +2 more 10 May 2013-Skeletal Muscle 29 Citations	Not addressed in the paper.
Open access•Journal Article•DOI The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2 Florian Glenewinkel, Michael J. Cohen, Cason R. King, Sophie Kaspar, Simone Bamberg-Lemper, Joe S. Mymryk, Walter Becker - Show less +6 more 16 Jun 2016-Scientific Reports 37 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12. Omar M. Khan, Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens - Show less +9 more 06 Apr 2021-Nature Communications 15 Citations	Not addressed in the paper.
Open access•Journal Article•DOI TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Li E. Wang, Peijing Zhang, David Molkentine, C-L Chen, Jessica M. Molkentine, Hai-long Piao, Hai-long Piao, Uma Raju, Jinsong Zhang, David Valdecanas, Ramesh C. Tailor, Howard D. Thames, Thomas A. Buchholz, Jack S.K. Chen, Li Ma, Kathryn A. Mason, K. Kian Ang, Raymond E. Meyn, Heath D. Skinner - Show less +18 more 09 Feb 2017-Oncogene 39 Citations	Not addressed in the paper.
Open access•Journal Article•DOI DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B. Mina Yousefelahiyeh, Jingyi Xu, Estibaliz Alvarado, Yang Yu, David Salven, Robert M. Nissen - Show less +5 more 29 Nov 2018-PLOS ONE 9 Citations	Not addressed in the paper.

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