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Bruce E. Clurman
Researcher at Fred Hutchinson Cancer Research Center
Publications - 88
Citations - 12704
Bruce E. Clurman is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Ubiquitin ligase & Cyclin-dependent kinase. The author has an hindex of 44, co-authored 86 publications receiving 11630 citations. Previous affiliations of Bruce E. Clurman include University of Washington.
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
TL;DR: Structural and functional aspects of FBW7, the substrate recognition component of an evolutionary conserved SCF, and its role in the development of cancer are focused on.
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Cyclin E-CDK2 is a regulator of p27Kip1.
TL;DR: In this article, a kinetic analysis of the interaction between p27 and cyclin E-CDK2 explains how p27 can be regulated by the same enzyme it targets for inhibition.
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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
Markus Welcker,Amir Orian,Jianping Jin,Jonathan A. Grim,Jonathan A. Grim,J. Wade Harper,Robert N. Eisenman,Bruce E. Clurman,Bruce E. Clurman +8 more
TL;DR: It is shown that Fbw7, a component of the SCFFbw 7 ubiquitin ligase and a tumor suppressor, promotes proteasome-dependent c-Myc turnover in vivo and c- myc ubiquitination in vitro.
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil,Jonathan E. Grim,Peter Strack,Sudhir Rao,Deanne Tibbitts,Christopher Winter,James S. Hardwick,Markus Welcker,Jules P.P. Meijerink,Rob Pieters,Giulio Draetta,Rosalie C. Sears,Bruce E. Clurman,A. Thomas Look +13 more
TL;DR: It is shown that all seven leukemic cell lines with FBW7 mutations were resistant to the MRK-003 GSI and most of these resistant lines also failed to down-regulate the mRNA levels of the NOTCH targets MYC and DELTEX1 after treatment with MRk-003, implying that residual NOTCH signaling in T-ALLs with FBw7 mutations contributes to GSI resistance.