Edward A. Ganio

TL;DR: These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.

TL;DR: The capacity of mass cytometry to survey the human immune system in a relevant clinical context is demonstrated and mechanistically derived immune correlates point to diagnostic signatures, and potential therapeutic targets, that could postoperatively improve patient recovery.

TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.

TL;DR: This model not only significantly increased predictive power by combining all datasets, but also revealed novel interactions between different biological modalities, which provides the frameworks for future studies examining deviations implicated in pregnancy‐related pathologies including preterm birth and preeclampsia.

TL;DR: Results indicate that precisely timed changes in the plasma proteome during term pregnancy mirror a proteomic clock, and the exciting promise of such a clock is that deviations from its regular chronological profile may assist in the early diagnoses of pregnancy‐related pathologies, and point to underlying pathophysiology.