How many amino acids are in growth hormone?
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49 Citations | The deduced amino acid sequence shows two possible sites for signal peptide cleavage, suggesting that the mature forms of yellow tail growth hormone consist of 185 or 187 amino acids. |
34 Citations | However, these peptides have only weak activity compared to native growth hormone, suggesting that additional amino acid residues N-terminal to position 95 are required for full biologic activity. |
20 Citations | The evidence suggests that the availability of a single amino acid, valine, plays a regulatory role in the synthesis of a specialized cellular product and that growth hormone acts at some level to alter the availability of this essential amino acid. |
29 Citations | Recent findings indicate that excitatory amino acids (EAAs) can modulate growth hormone (GH) secretion in several mammalian species in vivo and in vitro. |
56 Citations | Deletion of all the amino acids except the 10 essential amino acids plus alanine resulted in a decreased weight gain to about 1/3 normal; indicating that although all the other amino acids could be synthesized, one or more of the dispensable amino acids may be required for maximal growth. |
142 Citations | Incubation of the isolated diaphragm of the hypophysectomized rat with growth hormone also increases the incorporation of labeled amino acids into the protein of the It is not likely, however, that this apparent increase in the rate of muscle protein synthesis can be attributed to the action of growth hormone on amino acid transport. |
66 Citations | Changes in a-aminoisobutyric acid distribution after growth hormone administration are therefore taken to mean a change in amino acid transport into cells (5). |
22 Citations | This regulation may be important in the utilization of α-amino nitrogen from glucogenic amino acids associated with growth hormone enhanced glucose production. |
56 Citations | This improved nitrogen retention is also reflected in the significantly low blood urea nitrogen levels in the recombinant human growth hormone group, which represents the efficient utilization of the infused amino acids for synthesis of proteins. |
58 Citations | Thus, growth hormone can stimulate amino acid incorporation into muscle protein when its effect on amino acid transport is blocked, su... |
Related Questions
Amino acids based Hormones5 answersAmino acids play a role in the regulation of hormone synthesis and secretion. They can stimulate or inhibit the release of pituitary, pancreatic, and gastrointestinal hormones. For example, tyrosine is the precursor for the synthesis of epinephrine, norepinephrine, and thyroid hormones. Arginine stimulates the secretion of insulin, growth hormone, prolactin, glucagon, and placental lactogen. Glutamine and leucine increase insulin release from the pancreas. Amino acids also induce the secretion of gastrointestinal hormones such as glucagon-like peptide-1, cholecystokinin, and ghrelin. The mechanism of hormone release induced by amino acids may involve membrane depolarization and certain receptors and transporters. Amino acids can also affect the release of human growth hormone. A single dose of an oral amino acid supplement was shown to significantly increase hGH levels in healthy adults.
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