scispace - formally typeset
Search or ask a question

Is chitosan characterized by biocompatibility, biodegradability and promotion of osteogenesis? 


Best insight from top research papers

Chitosan is indeed characterized by biocompatibility, biodegradability, and promotion of osteogenesis. Chitosan-based biomaterials have shown excellent biocompatibility , making them suitable for tissue engineering applications. These biomaterials are biodegradable, ensuring they can be safely absorbed by the body over time. Moreover, chitosan scaffolds have been found to promote osteogenesis , facilitating the growth of new bone tissue. The positive-charged characteristic of chitosan enhances its biocompatibility and muco-adhesion, further underlining its suitability for biomedical applications. Overall, chitosan's unique properties make it a valuable material for bone tissue engineering, offering a combination of biocompatibility, biodegradability, and osteogenic promotion.

Answers from top 5 papers

More filters
Papers (5)Insight
Yes, chitosan is characterized by biocompatibility, biodegradability, and promotion of osteogenesis, making it a valuable material for bone and dental engineering applications.
Yes, chitosan exhibits biocompatibility, biodegradability, and promotes osteogenesis, especially when combined with BMP-2 and PLA granules in hydrogel-based materials, as shown in the study.
Yes, chitosan is biocompatible, biodegradable, and promotes osteogenesis. It was functionalized with peptides (Vitronectin and BMP-2) to enhance osteoblast adhesion, proliferation, and differentiation towards osteoblastic phenotype.
Yes, chitosan in the chitosan-silica biocomposite exhibited biocompatibility, as shown by in vitro and in vivo studies, making it a promising material for bone tissue engineering.
Yes, chitosan is characterized by biocompatibility, biodegradability, and promotion of osteogenesis, especially when modified with non-thermal biocompatible plasma, enhancing osteogenic differentiation in bone marrow stem cells.

Related Questions

How does the presence of chitosan affect the process of in situ precipitation of calcium phosphate?5 answersThe presence of chitosan significantly influences the in situ precipitation of calcium phosphate. Chitosan plays a crucial role in directing the growth and assembly of calcium phosphate crystals, leading to the formation of unique structures like flower-like microparticles. Additionally, chitosan, when combined with simulated body fluid (SBF), promotes the formation of hydroxyapatite, a key component of bone tissue, providing insights into biomineralization mechanisms. Chitosan's impact extends to the realm of nanocomposite materials, where its addition to silicate cross-linked poly(ethylene oxide) enhances cellular adhesion, bioactivity, and biomineralization control, making it a valuable component for creating bioactive scaffolds for bone repair. Overall, chitosan's presence influences the morphology, structure, and properties of calcium phosphate-based materials, showcasing its versatility in biomineralization processes.
How does the presence of chitosan affect the formation of calcium phosphate crystals?5 answersThe presence of chitosan influences the formation of calcium phosphate crystals by affecting their physico-chemical properties and adherence strength to substrates. Chitosan incorporation into calcium phosphate layers results in the formation of a calcium-deficient hydroxyapatite structure when deposited at room temperature. Chitosan-coated calcium phosphate films exhibit oriented crystals and qualitative control of calcium phosphate phases, promoting the growth and nucleation of porous calcium phosphate coatings. Additionally, chitosan accelerates the hardening dynamics of calcium phosphate cement, reducing the amount of unreacted monomers and enhancing the hardening process. Chitosan, along with chitin, chelates calcium and phosphate ions, providing an ambiance for hydroxyapatite crystallite formation, leading to the formation of micro-crystallites with specific calcium to phosphate ratios. Overall, the presence of chitosan plays a crucial role in modifying the structure and properties of calcium phosphate crystals.
How does the presence of chitosan affect the growth rate of calcium phosphate crystals?5 answersThe presence of chitosan influences the growth rate of calcium phosphate crystals in various ways. Chitosan incorporation into calcium phosphate layers can lead to the formation of a calcium-deficient hydroxyapatite structure, affecting the physico-chemical properties. Additionally, chitosan accelerates the hardening dynamics of calcium phosphate cement, reducing the amount of unreacted monomers within the cement over time. Furthermore, chitosan-coated chitosan films with porous calcium phosphate coatings have shown the ability to induce the growth and nucleation of calcium phosphate crystals, mimicking natural tissue formation. Chitosan's presence in hydroxyapatite 3D scaffolds/composites does not significantly alter the Young's modulus or antimicrobial properties, making them suitable for biomaterial applications. The chitin-chitosan-hydroxyapatite system provides an ambiance for HA crystallite formation, resulting in a bioactive surface with good biocompatibility and a structure resembling native bone.
What are the current methods used for testing the in vitro biodegradability of CHITOSAN-BASED BIOACTIVE COATING?5 answersThe current methods for testing the in vitro biodegradability of chitosan-based bioactive coatings include assessing the cytotoxicity of Chitosan-Cu complexes on surrounding cells through the CCK-8 test kit, as demonstrated in a study by Erişen et al.. Additionally, the biodegradation control of chitosan materials can be achieved by using random copolymers based on glycidyl methacrylate and (fluoro)alkyl methacrylates as surface modifiers, as reported by Yus. Furthermore, the incorporation of poly(ethylene glycol) as a sacrificial additive in electrospinning can lead to the preparation of fully biodegradable chitosan/TMC nanofibers, enabling high swelling ability, controlled biodegradability, and in vitro and in vivo biocompatibility, as discussed by an article by an undisclosed author.
What factor that influence the characteristic of chitosan?5 answersThe characteristics of chitosan are influenced by various factors such as its molecular weight, concentration of acetic acid, chitosan flakes, and tripolyphosphate (TPP). Different molecular weights of chitosan affect its properties, with low molecular weight chitosan showing better transfection efficiency in gene therapy applications. Additionally, the molecular weight of chitosan impacts the color properties and rheological behavior of chitosan and gels when exposed to gamma irradiation. Moreover, the antibacterial activity and physical properties of chitosan membranes are influenced by the molecular weight of chitosan, with high-molecular-weight chitosan showing the best antibacterial activity against certain bacteria strains. These factors collectively play a crucial role in determining the overall characteristics and performance of chitosan in various applications.
What are the chitosan materials that can be used for corneal replacement?4 answersChitosan materials that can be used for corneal replacement include soluble chitosan crosslinked with gelatin and chondroitin sulfate to obtain blend membranes. Another option is the use of decellularized corneal matrix from pigs combined with chitosan to create a composite material. Additionally, chitosan-based green composites, such as chitosan nanocomposites and chitosan blends with natural fibers, have potential applications in corneal tissue engineering. Furthermore, corneal matrix cells can be co-cultured with chitosan scaffolds to construct tissue-engineered corneal matrices. These studies demonstrate the versatility of chitosan in corneal replacement materials and highlight its potential for use in corneal tissue engineering and biomedicine.

See what other people are reading

What is hoechst 33342 concentration for live cell staining?
5 answers
The optimal Hoechst 33342 concentration for live cell staining varies depending on the specific application. Research indicates that concentrations as low as 7-28 nM are suitable for staining nuclei without inducing cytotoxicity or affecting cell viability, proliferation, or signaling pathways. However, caution is advised as concentrations below 1 µM of SiR-Hoechst have been shown to induce DNA damage responses and G2 arrest in human cells. Additionally, Hoechst 33342 can be used in combination with Pyronin Y for measuring DNA and RNA content in live cells, allowing the distinction between quiescent and proliferating cells. It is crucial to consider the specific experimental conditions and desired outcomes when determining the appropriate concentration of Hoechst 33342 for live cell staining.
What is the mechanism pf tribulus terrestris in boosting athelitic performance?
5 answers
Tribulus terrestris (TT) boosts athletic performance through various mechanisms. Firstly, TT upregulates testosterone levels, enhancing muscular growth and physical performance. Secondly, TT extracts contain biologically active compounds like steroidal saponins and flavonoids, which aid in treating sexual and hormonal issues. Additionally, TT's phytopharmacological properties suggest potential benefits in improving libido, sexual desire, and athletic performance. However, clinical trials indicate that TT alone may not significantly improve androgenic status or physical performance in athletes. On the contrary, TT extracts have shown cytotoxic effects on breast cancer cells, inducing apoptosis through intrinsic and extrinsic pathways, which could indirectly impact athletic performance by promoting overall health and well-being.
Why is wistar albino rat use in research with reference and dates?
5 answers
Wistar albino rats are commonly used in research due to their well-established reference values for hepatic and renal parameters, aiding in experimental standardization and reducing the number of animals needed for studies. These rats have been utilized in studies assessing the effects of substances like aspartame on cardiovascular indices, highlighting their relevance in toxicological research. Additionally, Wistar albino rats have been employed in evaluating the hepatoprotective activity of substances against hepatoma, showcasing their significance in cancer research. The historical significance of using rats in biomedical research dates back over 160 years, emphasizing their crucial role in advancing scientific knowledge and exploring human diseases.
How depositon effect the tortuosity of the porous materials?
5 answers
Deposition can significantly impact the tortuosity of porous materials. Tortuosity, a crucial parameter characterizing porous media, is affected by deposition due to changes in the pore structure and connectivity. Geometric tortuosity, influenced by porosity and pore size distribution, can increase with reduced pore size even at constant porosity levels. The complexity of the porous medium, altered by deposition, can lead to variations in tortuosity, affecting diffusive transport within the material. Manipulating tortuosity through changes in pore size and distribution is essential for optimizing the effective diffusion coefficient and enhancing mixing in porous structures, highlighting the importance of understanding the impact of deposition on tortuosity in porous materials.
What is sentence construction difficulty in the context of stating the final answer when solving word problems in math?
5 answers
Sentence construction difficulty in stating the final answer when solving word problems in math can arise due to various factors such as lack of comprehension, vocabulary, incorrect use of operations, interchanging values, and carelessness. Additionally, the complexity of sentence structures, like center embeddings, can contribute to comprehension challenges for students. Providing contextual images alongside word problems may not significantly impact students' ability to correctly solve problems, indicating that the visual context might not always aid in overcoming sentence construction difficulties. Dynamic assessment can help identify students' difficulties in solving word problems and determine the necessary scaffolding required at different levels to address sentence construction challenges effectively.
What is the biological importance of uric acid in aqueous humor?
4 answers
Uric acid in aqueous humor plays a significant role in various eye conditions. Studies have shown that elevated levels of uric acid in the aqueous humor are associated with the pathogenesis of posterior subcapsular cataract (PSC). Additionally, uric acid levels in the aqueous humor have been linked to diabetic macular edema (DME), with higher levels correlating with more severe DME cases. Furthermore, uric acid has been identified as a potent endogenous antioxidant in the eye, potentially influencing the development of cataracts. These findings suggest that uric acid in the aqueous humor may serve as a biomarker for ocular conditions and could be targeted for therapeutic interventions in diseases like PSC and DME.
What is the biggest advancement in tissue engeneering?
5 answers
The most significant advancement in tissue engineering lies in the utilization of cutting-edge technologies such as three-dimensional bioprinting, organ-on-a-chip systems, and induced pluripotent stem cell technologies. These innovations have revolutionized the field by enabling the creation of complex tissue constructs for regenerative medicine and disease modeling. Additionally, the development of biologically active scaffolds based on extracellular matrix analogues has played a crucial role in tissue and organ regeneration. Tissue engineering aims to restore or construct whole tissues using mesenchymal stem cells, signaling molecules, and scaffolds, reducing the need for extensive reconstructive surgery. The focus on functional product development anchored in disease state needs, along with collaborative research efforts, has shown significant translational potential in tissue engineering.
Has butyrate been successfully delivered to cancer cells?
5 answers
Yes, butyrate has been successfully delivered to cancer cells in various studies. Research has shown that butyrate can be encapsulated in nanoparticles to enhance its uptake by hepatocellular carcinoma (HCC) cells, inducing potent ferroptosis. Additionally, a study utilized a modified chitosan nano-complex to deliver sodium butyrate to prostate cancer cells, effectively suppressing cell growth and inducing apoptosis and autophagy. Moreover, bacterial cancer therapy using butyrate-producing Escherichia coli was developed to target human colorectal cancer cells, resulting in cell cycle arrest and apoptosis induction. Furthermore, butyrate has been found to enhance erastin-induced ferroptosis in lung cancer cells by modulating specific pathways, suggesting its potential as a therapeutic agent for cancer treatment. These studies collectively demonstrate successful delivery of butyrate to cancer cells for various therapeutic purposes.
Neural tissue engineering materials?
5 answers
Neural tissue engineering (NTE) relies on advanced materials to facilitate nerve repair and regeneration. Collagen stands out as a popular choice due to its compatibility with neural cells and ability to support growth and differentiation. Carbon-based nanomaterials like graphene and carbon nanotubes have also shown promise in driving neural tissue repair and regeneration. Additionally, polymeric scaffolds, both natural and synthetic, play a crucial role in nerve recovery by providing a conducive environment for axonal growth and cell survival. The ideal neural tissue engineering material should support cellular functions, minimize inflammation, enable electrochemical communication, mimic brain-like mechanical properties, and allow controlled substance release. These diverse materials offer a range of benefits and challenges, contributing to the advancement of neural tissue engineering for treating neurological disorders.
Ticagrelor inhibitory effect on activation of NF-kB signaling pathway?
5 answers
Ticagrelor exhibits inhibitory effects on the activation of the NF-κB signaling pathway. It prevents the degradation of IKBα, phosphorylation of p65, and the translocation of p65 into the nucleus, thereby reducing the production of inflammatory factors like TNFα, IL-1, IL-8, IL-6, and IL-2. Ticagrelor also downregulates NF-κB and galectin-3 expressions, along with IL-6 and TNF-α levels, in ischemic conditions. Moreover, ticagrelor inhibits the NLRP3 inflammasome activation independent of its classic P2Y12 inhibitory effect, showing promise in mitigating systemic inflammation. These findings collectively suggest that ticagrelor's modulation of the NF-κB pathway contributes to its anti-inflammatory properties, highlighting its potential therapeutic role in conditions involving NF-κB-mediated inflammation.
How does the interface between an electroconductive scaffold and medium behave under applied electrical stimulation?
5 answers
The interface between an electroconductive scaffold and medium under applied electrical stimulation influences cell behavior and differentiation. Conductive scaffolds, such as chitosan-polyaniline substrates, when combined with electrical stimulation, promote neural-like phenotypes in stem cells, enhancing nerve tissue engineering outcomes. Carbon nanofiller-based scaffolds, synchronized with electrical stimulation, show promise in nerve tissue repair due to their excellent electrical properties and biocompatibility. In cardiac tissue engineering, external electrical stimulation in conductive scaffolds affects cardiomyocyte behavior positively, leading to improved function and tissue construct optimization. Additionally, electroconductive scaffolds combined with electrical stimulation guide adipose-derived stem cells towards neurogenic differentiation, indicating potential applications in nerve injury regeneration. These findings collectively highlight the significant impact of the electroconductive scaffold-medium interface under electrical stimulation on directing cell behavior and differentiation for tissue engineering applications.