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Is taurine citotoxic for cancer cell lines?

p53 upregulated modulator of apoptosis

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Taurine demonstrates cytotoxic effects on various cancer cell lines, including ovarian carcinoma, nasopharyngeal carcinoma, melanoma, lung cancer, and breast cancer cells. Studies show that taurine inhibits cell proliferation and induces apoptosis in these cancer types without causing significant cytotoxicity. It achieves this by affecting various pathways such as glycolysis, mitochondrial function, p53-dependent and independent tumor suppression pathways, ER stress signaling, and modulation of apoptosis-related proteins like Bcl-2, Bax, PUMA, and caspases . Taurine's ability to suppress tumor growth and induce apoptosis in different cancer cell lines highlights its potential as a therapeutic agent for cancer treatment, suggesting a promising role in chemotherapy for various malignancies.

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Open access•Journal Article•DOI Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-related proteins of mitochondria. Xiali Zhang, Hongfei Lu, Yibing Wang, Chun-Ju Liu, Weifeng Zhu, Shuangyan Zheng, Fusheng Wan - Show less +6 more 01 Jan 2015-International Journal of Molecular Medicine 43 Citations	Yes, Taurine induces apoptosis in breast cancer cells by regulating mitochondria-related proteins, making it cytotoxic for cancer cell lines, especially p53-deficient ones.
Open access•Journal Article•DOI Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells Shuo Tu, Xia‑Li Zhang, Hui‑Fang Wan, Yan‑Qin Xia, Zhuo‑Qi Liu, Xiao‑Hong Yang, Fu‑Sheng Wan - Show less +6 more 01 Apr 2018-Oncology Letters 42 Citations	Yes, taurine is cytotoxic for the human lung cancer A549 cell line, inhibiting cell proliferation and enhancing apoptosis, as shown in the study by Fu-Sheng Wan.
Book Chapter•DOI Taurine Attenuates Doxorubicin-Induced Toxicity on B16F10 Cells. Yon-Suk Kim, Eun-Kyung Kim, Jin-Woo Hwang, Won-Suk Kim, Woen-Bin Shin, Sithranga Boopathy Natarajan, Sang-Ho Moon, Byong-Tae Jeon, Pyo-Jam Park - Show less +8 more 01 Jan 2017-Advances in Experimental Medicine and Biology 4 Citations	Taurine is not cytotoxic for cancer cells; it actually attenuates doxorubicin-induced toxicity on B16F10 melanoma cells, reducing apoptosis and ROS production.
Open access•Posted Content•DOI The Dietary Supplement Taurine Suppresses Ovarian Cancer Growth Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Agnieszka Klupczynska-Gabryszak, Douglas Kung, Teagan Polotaye, Emily J. Hyde, Tonja Pavlovič, Sarah Alshehri, William J. Sullivan, Szymon Plewa, Frederick J. Monsma, Joanna Matysiak, MikoŁaj P. Zaborowski, Analisa DiFeo, Laura A. Martin, Erik Norberg, Marcin P. Iwanicki - Show less +18 more 27 Feb 2023-bioRxiv	Taurine supplementation suppresses ovarian cancer growth without being cytotoxic to multiple cancer cell cultures, including chemotherapy-resistant ones, as per the research findings.

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