M
Marcin P. Iwanicki
Researcher at Stevens Institute of Technology
Publications - 38
Citations - 4110
Marcin P. Iwanicki is an academic researcher from Stevens Institute of Technology. The author has contributed to research in topics: Ovarian cancer & Integrin. The author has an hindex of 21, co-authored 33 publications receiving 3421 citations. Previous affiliations of Marcin P. Iwanicki include Harvard University & University of Virginia Health System.
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Journal ArticleDOI
Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer
David D.L. Bowtell,David D.L. Bowtell,Steffen Böhm,Ahmed Ashour Ahmed,Paul Joseph Aspuria,Robert C. Bast,Valerie Beral,Jonathan S. Berek,Michael J. Birrer,Sarah P. Blagden,Michael A. Bookman,James D. Brenton,Katherine B. Chiappinelli,Filipe C. Martins,George Coukos,Ronny Drapkin,Richard J. Edmondson,Christina Fotopoulou,Hani Gabra,Jérôme Galon,Charlie Gourley,Valerie Heong,David G. Huntsman,Marcin P. Iwanicki,Beth Y. Karlan,Allyson Kaye,Ernst Lengyel,Douglas A. Levine,Karen H. Lu,Iain A. McNeish,Usha Menon,Steven A. Narod,Brad H. Nelson,Kenneth P. Nephew,Paul D.P. Pharoah,Daniel J. Powell,Pilar Ramos,Iris L. Romero,Clare L. Scott,Anil K. Sood,Euan A. Stronach,Frances R. Balkwill +41 more
TL;DR: This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015 and aims to reduce incidence and improve outcomes for women with this disease.
Journal ArticleDOI
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Patricia A.J. Muller,Patrick T. Caswell,Brendan Doyle,Marcin P. Iwanicki,Ee H. Tan,Saadia A. Karim,Natalia Lukashchuk,David A. F. Gillespie,Robert L. Ludwig,Pauline Gosselin,Anne Cromer,Joan S. Brugge,Owen J. Sansom,Jim C. Norman,Karen H. Vousden +14 more
TL;DR: It is shown that Mutant p53 expression can promote invasion, loss of directionality of migration, and metastatic behavior, and the possibility that blocking alpha5/beta1-integrin and/or the EGF receptor will have therapeutic benefit in mutant p53-expressing cancers is opened.
Journal ArticleDOI
Cellular characterization of a novel focal adhesion kinase inhibitor.
Jill K. Slack-Davis,Karen H. Martin,Robert W. Tilghman,Marcin P. Iwanicki,Ethan Ung,Christopher Autry,Michael Joseph Luzzio,Beth Cooper,John Charles Kath,W. Gregory Roberts,J. Thomas Parsons +10 more
TL;DR: P perturbation of adhesion-mediated signaling with a FAK inhibitor, PF-573,228, serves as a useful tool to dissect the functions of FAK in integrin-dependent signaling pathways in normal and cancer cells and forms the basis for the generation of compounds amenable for preclinical and patient trials.
Journal ArticleDOI
Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
Taru A. Muranen,Laura M. Selfors,Devin Worster,Marcin P. Iwanicki,Loling Song,Fabiana C. Morales,Sizhen Gao,Gordon B. Mills,Joan S. Brugge +8 more
TL;DR: It is shown that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells are resistant.
Journal ArticleDOI
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium
Marcin P. Iwanicki,Rachel A. Davidowitz,Mei Rosa Ng,Achim Besser,Taru A. Muranen,Melissa A. Merritt,Gaudenz Danuser,Tan A. Ince,Tan A. Ince,Joan S. Brugge +9 more
TL;DR: Evidence is provided that ovarian cancer spheroids utilize integrin- and talin- dependent activation of myosin and traction force to promote mesothelial cells displacement from underneath a tumor cell spheroid, suggesting that ovarian tumor cell clusters gain access to the sub-mesothelial environment by exerting force.