Is TRPV4 involved in thermosensation?
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Yes, TRPV4 is involved in thermosensation. TRPV4 is a polymodal cellular sensor that responds to moderate heat, cell swelling, and small-molecule ligands . Additionally, TRPV4 is known to be activated by physiological temperature, acting as a molecular temperature sensor and playing a crucial role in temperature-dependent immune activation . Furthermore, studies have shown that TRPV4 can coassemble with TRPV3 into functional heterotetrameric channels, contributing to the fine-tuning of environmental detection and temperature sensation in mammals . These findings highlight the role of TRPV4 in thermosensation, indicating its involvement in detecting temperature changes and modulating cellular responses accordingly.
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2 Citations | Yes, TRPV4 is involved in thermosensation as it acts as a molecular temperature sensor, being activated by physiological temperature, which plays a crucial role in temperature-dependent immune activation. |
| Yes, TRPV4 is involved in thermosensation as it responds to moderate heat among other stimuli, playing a role in thermogenesis and various physiological functions. | |
| Yes, TRPV4 is involved in thermosensation as it can coassemble with TRPV3 to form heterotetrameric channels, contributing to fine-tuning temperature detection and sensation in the skin. | |
20 Citations | Not addressed in the paper. |
| Yes, TRPV4 is involved in thermosensation as it interacts with TRPV1 to amplify Ca2+ signaling and induce lung injury in response to different inspired gas temperatures. |
Related Questions
How does TRPV influence regerneration of olfactory receptor neuron?5 answersTRPV channels play a crucial role in olfactory memory consolidation and sensory neuron function. Studies have shown that TRPV2 is predominantly expressed in olfactory sensory neurons (OSNs) and is involved in the growth of olfactory axons, indicating its importance in the olfactory system. Additionally, TRPV channels, including OSM-9/TRPV5/TRPV6, have been linked to short-term and long-term olfactory memory formation in C. elegans, with OSM-9 specifically implicated in memory consolidation induced by repeated training with specific odors. Furthermore, TRPV1 has been associated with olfactory discrimination deficits when influenced by pharmacological agents like rimonabant, highlighting the intricate role of TRPV channels in olfactory functions. Overall, TRPV channels influence olfactory receptor neuron regeneration by modulating sensory neuron activity and memory consolidation processes.
Where is TRPV1 abundant in the body?3 answersTRPV1 is abundant in various organs including the kidneys, adrenal gland, spleen, brain, dorsal root ganglion (DRG), and spinal cord (SC). It is expressed by peripheral nociceptors and is involved in inflammatory and neuropathic pain conditions. TRPV1 is also found in the heart, specifically in the transient receptor potential vanilloid type 1 (TRPV1)-containing afferent nerve fibers. Activation of TRPV1 in sensory neurons leads to the release of pro-inflammatory factors and modulation of sensory input to the central nervous system, which affects core body temperature. Additionally, TRPV1 activation in vascular smooth muscle cells promotes arteriole constriction. These findings suggest that TRPV1 is involved in various physiological functions and can be targeted for the control of body weight and inflammatory pain.
What is TRPV1 signal about pain management or inflammation?5 answersTRPV1 is a cation channel involved in pain management and inflammation. It is activated by various stimuli such as heat, low pH, inflammatory agents, and endogenous agonists like capsaicin and lysophosphatidic acid (LPA). TRPV1 plays a central role in pain sensation and is expressed in primary afferent neurons that respond to damaging or potentially damaging stimuli. Pharmacological studies have shown that TRPV1 antagonists can be effective in chronic pain management, but their clinical use is limited due to side effects like hyperthermia. On the other hand, capsaicin, a TRPV1 agonist, can induce a prolonged defunctionalization of nociceptors, offering a potential therapeutic option for long-lasting pain relief. TRPV1 is also involved in inflammatory responses and hypersensitivity, making it a potential target for the treatment of inflammatory pain.
What are the parameters on TRPV6 B chain?5 answersThe parameters on TRPV6 B chain are not mentioned in the provided abstracts.
What are the effects of TRPV4 interaction with microtubules on the function of TRPV4 channels?5 answersTRPV4 interacts with microtubules, which influences cellular mechanosensitive processes and the development of mechanical hyperalgesia. The exact molecular and functional level of this interaction is not known. However, recent data suggest a direct interaction between TRPV4 and the cytoskeleton, including microtubules. This interaction has functional repercussions for both TRPV4 and the cytoskeleton. The cytoskeleton components act as modulators and downstream effectors of TRPV4 channels, affecting their function. The interplay between TRPV4 and the cytoskeleton, including microtubules, serves as a potent integration point for complex biological signaling events. These findings suggest that the interaction between TRPV4 and microtubules plays a role in modulating the function of TRPV4 channels, although the specific effects are not yet fully understood.
What is the role of TRP channels in taste and olfaction?4 answersTransient receptor potential (TRP) channels play a crucial role in taste and olfaction. TRP channels are cation transmembrane proteins that respond to sensory stimuli and are expressed in various tissues. In taste perception, TRP channels, such as TRPM5, are activated by food/chemicals and are essential for acquiring nutrients and detecting taste stimuli. Dysfunctional TRP channels have been associated with neuropathic pain, inflammation, and altered taste sensitivity. In olfaction, TRP channels, including TRPC2, TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5, are expressed in sensory neurons and are involved in signal transduction of pheromones and other molecular cues. TRPC2 knockout mice show altered social behaviors, indicating the importance of TRP channels in olfactory function. Overall, TRP channels have a significant role in both taste and olfaction, contributing to sensory perception and the modulation of various taste and odor qualities.