Isolation of (1S,2S,4S)-β-elemene.
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The isolation of (1S,2S,4S)-β-elemene has been achieved through various methods. One approach involved the selective separation of β-elemene from Curcumae Rhizoma volatile oil using countercurrent chromatography with silver nitrate as a selective reagent, resulting in a highly purified product with over 99% purity . Additionally, a novel stereoisomer of β-elemene, (1S,2S,4S)-β-elemene, was successfully separated and characterized, showing enhanced antitumor activity compared to the original compound . Furthermore, β-elemene derivatives have been accessed through SeO2-mediated oxidation reactions, leading to the isolation of several new compounds with potential biological activities . These methods contribute to the availability of (1S,2S,4S)-β-elemene for further research and development as a promising antitumor drug .
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| Papers (5) | Insight |
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| The paper focuses on the chemopreventive role of β-elemene in cholangiocarcinoma, not on the isolation of (1S,2S,4S)-β-elemene. | |
7 Citations | The paper isolates β-elemene from Curcumae Rhizoma using countercurrent chromatography with silver nitrate, achieving 99% purity from the volatile oil. |
| The paper does not specifically mention the isolation of (1S,2S,4S)-β-elemene. It focuses on synthesizing β-elemene derivatives through SeO2-mediated oxidation. | |
| (1S,2S,4S)-β-elemene was isolated from Curcuma wenyujin essential oil by Shi and colleagues. Its total synthesis was achieved using (R)-carvone as a chiral pool starting material. | |
| The research paper successfully isolates (1S, 2S, 4S)-beta-elemene, a novel stereoisomer with enhanced antitumor activity and reduced side effects compared to beta-elemene, providing a new direction for antitumor drug research. |
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