Patients with non-small cell lung cancer developed resistance to oxitinib after one year of treatment. What's the next step?
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Patients with non-small cell lung cancer who develop resistance to osimertinib after one year of treatment have several potential next steps. One option is to explore the remodelling of the tumor microenvironment after osimertinib treatment resistance, as evidence suggests that acquired resistance is linked to the mutual domestication between the tumor and its surrounding microenvironment . Another option is to consider afatinib rechallenge after osimertinib resistance, as afatinib has demonstrated activity against certain uncommon EGFR mutation types . Additionally, it is important to characterize the genomic landscape of primary resistance to osimertinib, as EGFR-independent alterations are common among patients with primary resistance and significantly impact progression-free survival and overall survival . Finally, it is crucial to continue researching and developing new therapeutic strategies to overcome resistance to EGFR-TKIs, as intrinsic and acquired resistance remains a challenge in the treatment of non-small cell lung cancer .
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| The provided paper does not specifically mention oxitinib. Therefore, we cannot find information about the next step for patients with non-small cell lung cancer who developed resistance to oxitinib in this paper. The paper is about therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance. | |
| The provided paper does not mention the specific drug "oxitinib" or its resistance in non-small cell lung cancer patients. | |
| The provided paper does not mention the use of oxitinib or the next step for patients with non-small cell lung cancer who develop resistance after one year of treatment. | |
| The provided paper does not mention oxitinib. |
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