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What are some risk factors for the hardening of arteries? 

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CKD worsens classical risk factors including hypertension and dyslipidemia, and dyslipidemia is associated with increased thickness and stiffness of large arteries independent of major confounders.
Some risk factors affect one lesion type or one arterial segment more than another; Smoking and diabetes appears to be of particular importance in coronary arteries and the abdominal aorta, while hypertension increases risk of accelerated atherosclerosis in all parts of the arterial system.
Prominent risk factors include the hardening of arteries and high levels of cholesterol, which lead to the initiation and progression of atherosclerosis.
Cardiovascular risk factors impair compensatory arterial enlargement and even predispose to shrinkage of epicardial arteries during the initial stage of atherosclerosis.
These findings suggest that exposure to cardiovascular risk factors early in life may induce changes in arteries that contribute to the development of atherosclerosis.
Recognized risk factors for coronary heart disease are associated with lesion development and progression in the arteries of youth, already affecting coronary arteries and the aorta during the second and third decades of life and possibly earlier.
Increased thickness and stiffness of large arteries may contribute to why aging is the most important risk for cardiovascular diseases.
Elastic arteries are stiffer in diabetes independent of traditional risk factors.
Deconditioning, old age, abdominal obesity, and other cardiovascular disease risk factors may do just the opposite, in effect, causing 'localized hypertension' in clinically important arteries.
Coronary arteries are significantly more affected than other arterial territories regardless of risk factors, showing the effect of local and systemic factors in the severity of atherosclerosis.

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