What are the adverse reactions for calcium?5 answersCalcium can induce various adverse reactions. Cutaneous adverse effects are common, with calcium channel blockers like diltiazem showing high rates of cutaneous reactions, including maculopapular rash and severe conditions like Stevens-Johnson syndrome and toxic epidermal necrolysis. Calcium supplements have been linked to increased self-reported gastrointestinal adverse events, such as constipation and abdominal cramping, potentially leading to misperception of myocardial infarction. Moreover, calcium supplements, especially in combination with vitamin D, have been associated with heightened cardiovascular risks like myocardial infarction and stroke, potentially outweighing their benefits on fracture incidence. Additionally, nadroparin calcium injections have been reported to cause localized skin reactions like erythema and generalized urticaria-like reactions in pregnant women.
What are the potential limitations of using Acta2-RCaMP1.07 in studying calcium activity in cells.?4 answersThe potential limitations of using Acta2-RCaMP1.07 in studying calcium activity in cells include the need for standardized and accurate analysis methods due to the large datasets generated by cellular calcium fluorescence imaging. Additionally, assumptions of non-negativity in neuronal responses detected by calcium indicators can bias analytical methods, potentially leading to missed real responses, especially in inhibited neurons. Popular algorithms for image analysis like CaImAn, suite2p, and CellSort may have limitations in dealing with inhibited neurons, requiring new approaches for accurate spike inference in such cases. Despite advances in genetically encoded calcium indicators (GECIs) like GCaMP6, limitations in affinity, signal-to-noise ratio, and dynamic range still persist, emphasizing the ongoing challenges in calcium imaging techniques.
What is the effect of Ca on Mg corrosion?5 answersThe addition of Ca to Mg alloys has been found to have a positive effect on corrosion resistance. The presence of Ca refines the grain structure of the alloys and leads to the formation of protective corrosion product films. The refinement of the grain structure and the formation of protective films contribute to the reduction of corrosion rates in various electrolytes, such as NaCl and Na2SO4. The addition of Ca also introduces new phases, such as Ca2Mg6Zn3, which further enhance the corrosion resistance of the alloys. Overall, the presence of Ca in Mg alloys improves their corrosion resistance by refining the grain structure, forming protective films, and introducing new phases.
What are the disadvantages of Akermanite as biomaterials?4 answersAkermanite has shown promising potential as a biomaterial for various applications such as bone healing, mechanical properties, and wound healing. However, there are no specific disadvantages of Akermanite as a biomaterial mentioned in the provided abstracts. The abstracts mainly focus on the positive aspects and potential applications of Akermanite, such as its ability to enhance cell proliferation, osteogenic differentiation, angiogenic factor expression, and wound healing. Additionally, the abstracts highlight the mechanical properties of Akermanite, such as microhardness and fracture toughness, which make it suitable for non-load bearing applications. Therefore, based on the information provided in the abstracts, there are no explicit disadvantages mentioned for Akermanite as a biomaterial.
What are the disadvantages of calcium sulphate as biomaterials?3 answersCalcium sulphate as a biomaterial has some disadvantages. One limitation is that it has not enjoyed the popularity of many other regenerative materials, although there has been a recent resurgence of interest in the material. Another disadvantage is that when used in isolation, calcium sulphate is not optimal for promoting union in bone nonunions, as it has shown a significant failure rate in such cases. Additionally, the release of high quantities of calcium ions from calcium sulphate may negatively affect human osteoblasts, which can be a concern. Furthermore, the reduction in calcium levels achieved by calcium-chelating polysaccharides, such as sodium alginate, in the presence of calcium sulphate is not long-lasting, which may limit its long-term effectiveness. These limitations and concerns highlight the need for further research and modification of calcium sulphate as a biomaterial.
What are the shortcomings in methods to recover calcium from waste concrete?4 answersMethods to recover calcium from waste concrete have some shortcomings. One limitation is the high porosity and water absorption rate of recycled concrete aggregate, which affects the properties of the concrete made with it. Another issue is the presence of microcracks in the interfacial transition zones of the recycled aggregate, which can reduce its durability. Additionally, the calcium hydroxide (Ca(OH)2) content of the recycled aggregate can be high, which is undesirable. To address these shortcomings, various methods have been proposed. These include carbon dioxide enhanced treatment, which effectively fills microcracks and reduces porosity. Other methods involve calcining the material at high temperatures and carrying out ball milling to improve its properties. Some approaches also focus on using mineral admixtures such as fly ash, silica fume, and ground granulated blast furnace slag to enhance the properties of the recycled aggregate.