What are the mechanisms that control the survival and function of long-lived plasma cells?
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Long-lived plasma cells, also known as memory plasma cells, are able to persist for long periods of time and continue to secrete antibodies. The survival and function of these cells are regulated by several mechanisms. One key regulator is the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) molecule Sec22b, which is essential for plasma cell survival and the humoral immune response . The microenvironment also plays a crucial role in the survival of long-lived plasma cells. Factors in the microenvironment, such as prosurvival factors and integrin-mediated contact with stromal cells, provide essential survival signals to the plasma cells . Additionally, the activation of signaling pathways, such as NF-kB- and PI3K-dependent pathways, and the prevention of apoptosis through the downregulation of caspases, contribute to the survival and function of long-lived plasma cells . These mechanisms collectively ensure the persistence and functionality of long-lived plasma cells in the immune system.
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8 Citations | The mechanisms that control the survival and function of long-lived plasma cells include integrin-mediated contact with stromal cells and the cytokines BAFF and APRIL. |
| The mechanisms that control the survival and function of long-lived plasma cells are the signals provided by dedicated survival niches in the bone marrow, such as secreted factors APRIL and direct contact with stromal cells. These signals activate NF-kB- and PI3K-dependent signaling pathways to prevent cell death. | |
11 Citations | The paper does not provide information about the mechanisms that control the survival and function of long-lived plasma cells. The paper focuses on the biochemical processes involved in plasma cell genesis and secretion of antibodies. |
| The paper discusses the generation of IgE+ long-lived plasma cells (LLPCs) and the prosurvival factors in their microenvironment, but does not clearly identify the mechanisms that control their survival and function. | |
| The paper does not provide information about the mechanisms that control the survival and function of long-lived plasma cells. The paper focuses on the role of the SNARE molecule Sec22b in plasma cell survival and its implications for antibody-mediated immunity. |
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