F
Françoise Bachelerie
Researcher at Université Paris-Saclay
Publications - 94
Citations - 10403
Françoise Bachelerie is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Chemokine receptor & Chemokine. The author has an hindex of 39, co-authored 83 publications receiving 9392 citations. Previous affiliations of Françoise Bachelerie include University of California, Los Angeles & University of Paris-Sud.
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Journal ArticleDOI
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Estelle Oberlin,Ali Amara,Françoise Bachelerie,Christine Bessia,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Olivier Schwartz,Jean-Michel Heard,Ian Clark-Lewis,Daniel F. Legler,Marcel Loetscher,Marco Baggiolini,Bernhard Moser +12 more
TL;DR: The identification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and the term CXCR-4 is proposed for this receptor, in keeping with the new Chemokine-receptor nomenclature.
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The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.
Karl Balabanian,Bernard Lagane,Simona Infantino,Ken Y.C. Chow,Julie Harriague,Barbara Moepps,Fernando Arenzana-Seisdedos,Marcus Thelen,Françoise Bachelerie +8 more
TL;DR: It is demonstrated that RDC1 is expressed in T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 monoclonal antibody, and it is shown that CxCL12, the only known natural ligand for CXCR4, binds to and signals through R DC1.
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Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export
Batool Ossareh-Nazari,Françoise Bachelerie,Françoise Bachelerie,Catherine Dargemont,Catherine Dargemont +4 more
TL;DR: The CRM1 protein could act as a NES receptor involved in nuclear protein export in a system which reconstituted NES, cytosol, and energy-dependent nuclear export, and leptomycin B specifically blocked export of NES-containing proteins.
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International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
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CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.
TL;DR: It is shown that CXCR7 per se does not trigger G( Ralphai) protein-dependent signaling, although energy transfer assays indicate that it constitutively interacts with G(alphai) proteins and undergoes CXCL12-mediated conformational changes.