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In vitro, single isolated neurons from each of these populations grow at a similar rate to that observed in vivo, indicating that growth rate is an intrinsically determined property of neurons before they reach their targets.
The regeneration of these neurons shows that neurons differentiated from stem cells have the capacity to grow to a specific target in an animal model of neuronal degeneration.
There is a trend within the DRG population for large neurons to be born before small neurons.
Within the same culture, neurons will grow onto sciatic nerve rather than neighboring optic nerve sections, suggesting that the responsible agent(s) is not soluble.
Later forming ganglia of the same type may grow along existing pathways of earlier formed neurons.
This strategy could be greatly enhanced by providing the sprouting neurons with a permissive substrate upon which to attach and grow.
The similarities between the ability of identified neurons to grow and to form synaptic connections in situ and in culture suggests that neurons are endowed with a specific program of regenerative responses that can be expressed reliably in a wide variety of environmental conditions.
Oligodendrocytes, in a fashion similar to that of neurons appear to keep their body immobile while the long processes grow.