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What is the current understanding of the role of ADM in the development and progression of breast cancer?

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Antibody-drug conjugates (ADCs) have revolutionized breast cancer treatment by delivering potent chemotherapy specifically to cancer cells while sparing normal cells . These ADCs consist of an antibody targeting a tumor antigen, a cytotoxic payload, and a linker connecting the two components. Despite the challenges of off-target toxicities and drug resistance, innovative non-internalizing ADCs targeting the tumor microenvironment have shown promise in reducing resistance and enhancing effectiveness. Additionally, the recent approval of ADCs like sacituzumab govitecan and trastuzumab deruxtecan, along with ongoing clinical trials, signifies a growing field with improved therapeutic options for breast cancer patients. Understanding the mechanisms of ADC action and their potential in breast cancer therapy highlights the evolving landscape of targeted treatments for this disease.

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Open access•Journal Article•DOI New antibody-drug conjugates (ADCs) in breast cancer—an overview of ADCs recently approved and in later stages of development Kira-Lee Koster, Jens Huober, Markus Joerger - Show less +2 more 24 Feb 2022-Exploration of targeted anti-tumor therapy 6 Citations	ADCs play a crucial role in breast cancer treatment by combining specific antibodies with potent cytotoxic agents, enhancing therapeutic efficacy with improved safety profiles in advanced and potentially early-stage breast cancer.
Open access•Journal Article•DOI Advances in Targeted Therapy of Breast Cancer with Antibody-Drug Conjugate Md. Abdus Subhan, Vladimir P. Torchilin - Show less +1 more 01 Apr 2023-Pharmaceutics	ADCs play a crucial role in targeted therapy for breast cancer by delivering potent cytotoxic agents to tumor cells, overcoming drug resistance, and reducing off-target effects, enhancing therapeutic efficacy.
Open access•Posted Content•DOI The role of epigenetics in cancer development and progression Muyassarxon Baxriddinova 05 Apr 2023	Not addressed in the paper.
Journal Article•DOI Current and Emerging Role of Antibody-Drug Conjugates in HER2-Negative Breast Cancer. Rachel Occhiogrosso Abelman, Jennifer Keenan, P.K. Ryan, Laura Spring, Aditya Bardia - Show less +4 more 01 Feb 2023-Hematology-oncology Clinics of North America	Not addressed in the paper.

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