What is the effect of HERC1 on lung cancer survival?
Best insight from top research papers
HERC1 has been identified as a gene that regulates cell migration and invasion in breast cancer, affecting primary tumor growth and lung colonization . In lung cancer, RAC1 has been found to promote cell survival, migration, and metastasis, leading to radioresistance . The overexpression of HER2/neu has been associated with poor prognosis in non-small-cell lung cancer (NSCLC), with higher relapse rates and shorter median time to relapse . On the other hand, the decreased expression of hypermethylated in cancer 1 (HIC1) has been observed in lung cancer, and its loss promotes cell proliferation and migration . Therefore, while HERC1 has been shown to have an effect on breast cancer, its specific effect on lung cancer survival has not been directly addressed in the provided abstracts.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
19 Citations | The effect of HERC1 on lung cancer survival is not mentioned in the provided paper. The paper focuses on the role of RAC1 in promoting radioresistance and epithelial-mesenchymal transition in lung cancer. |
5 Citations | The provided paper does not mention the effect of HERC1 on lung cancer survival. The paper focuses on the role of hypermethylated in cancer 1 (HIC1) in lung cancer development and progression. |
25 Citations | The effect of HERC1 on lung cancer survival is not mentioned in the provided paper. The paper discusses the significance of HER2/neu overexpression on survival in non-small-cell lung cancer. |
6 Citations | The provided paper does not mention the effect of HERC1 on lung cancer survival. The paper focuses on the role of HERC1 in breast cancer cell migration and invasion. |
10 Citations | The provided paper is about the role of HERC1 in breast cancer, not lung cancer. There is no information in the paper about the effect of HERC1 on lung cancer survival. |
Related Questions
How apoptosis affects lung cancer?5 answersApoptosis, or programmed cell death, plays a crucial role in lung cancer. Abnormal regulation of apoptosis can lead to the development and progression of lung tumors. Several signaling pathways, such as NF-κB, PI3K/AKT, and MAPK, are involved in the regulation of apoptosis in lung cancer. MicroRNAs (miRNAs) and their target genes also play a significant role in apoptosis. MiR-146b, 146a, 21, 23a, 135a, 30a, 202, and 181 have been identified as key miRNAs involved in the apoptotic pathway, while IRAK1, TRAF6, Bcl-2, PTEN, Akt, PIK3, KRAS, and MAPK1 are classified as their target genes. Additionally, inhibitors of apoptosis, such as surviving, living, BRUCE, and XIAP, regulate apoptosis by controlling the expression of apoptosis-related genes and miRNAs. Understanding the mechanisms of apoptosis, including signaling pathways, miRNAs/target genes, and inhibitors, can provide valuable insights for the diagnosis, treatment, and prediction of drug response in lung cancer patients.
What are the effects of THC on cancer cells?4 answersTHC has been shown to have anti-tumorigenic effects on cancer cells, including colorectal carcinoma cells, melanoma cells, squamous cell carcinoma cells, and glioblastoma cells. These effects are mediated through various mechanisms, including the modulation of cannabinoid receptors CB1 and CB2, as well as other receptors such as GPR18 and GPR55. THC has been found to inhibit cell proliferation and induce cell cycle arrest in cancer cells. Additionally, THC has been shown to reduce inflammation and inhibit the expression of cytokines involved in inflammation. The anti-cancer activity of THC has been observed in different types of cancer cells, suggesting its potential as a therapeutic agent for cancer treatment.
What are the factors that affect overall survival in patients with lung cancer?3 answersFactors that affect overall survival in patients with lung cancer include smoking status, demographic and socioeconomic factors, first course surgery, histology, BMI, and stage of cancer. Malnutrition and systemic inflammatory responses are also associated with poor overall survival in lung cancer patients. Additionally, the presence of concomitant cardiovascular disease, cardiotoxicity of radiotherapy and chemoradiotherapy, and acute arterial and venous thromboembolic events can influence survival time. Occupational asbestos exposure may decrease overall survival in patients with lung cancer.
What is the effect of HERC2 on lung cancer survival?5 answersHERC2 mRNA expression has been found to have an effect on lung cancer survival. In a study by Bonanno et al., it was observed that among patients with low BRCA1 expression, those with low HERC2 levels had a longer median progression-free survival (PFS) compared to those with high HERC2 levels. Additionally, patients with low levels of both BRCA1 and HERC2 had a longer median overall survival (OS) compared to those with low BRCA1 but high HERC2 expression. The multivariate analysis showed that the combined low expression of both BRCA1 and HERC2 reduced the risk of progression and death among patients with Eastern Cooperative Oncology Group performance status 0-1. These findings suggest that HERC2 mRNA expression may have a predictive role in lung cancer and could potentially be used to refine the BRCA1 predictive model.
What is the role of HERC1 in fertility?5 answersHERC1 plays a role in bone homeostasis and bone formation, as well as in the regulation of presynaptic membrane dynamics. It has been shown that HERC1 deficiency leads to imbalanced bone homeostasis and osteopenia in mice, particularly in young female mice. Additionally, HERC1 has been implicated in the regulation of synaptic vesicles and synaptic endings in the hippocampus, suggesting a role in neuronal function. Furthermore, HERC1 has been identified as a gene that regulates tumor cell migration and invasion in breast cancer, and its expression levels are inversely correlated with overall survival in breast cancer patients. However, there is no specific mention of HERC1's role in fertility in the provided abstracts.
Does smoking increase the chance of lung cancer?4 answersSmoking is the greatest risk factor for lung cancer, although it is not a necessary or sufficient condition for the disease. Cigarette smoking explains almost 90% of lung cancer risk in men and 70 to 80% in women. However, only 10% of tobacco smokers develop lung cancer, indicating that other factors are involved. Occupational exposure to carcinogens such as asbestos, cadmium, and arsenic, as well as exposure to environmental tobacco smoke, residential radon, and environmental pollution, also increase the risk of lung cancer. Chronic inflammation resulting from smoking and genetic abnormalities may contribute to lung carcinogenesis. Quitting smoking has several benefits for lung cancer patients, and effective smoking cessation services should be implemented in oncology practices.