What is the mechanism by which mitomycin induces the production of Shiga toxin (Stx)?
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Mitomycin induces the production of Shiga toxin (Stx) by acting as an agent that triggers the induction of Shiga toxin-converting prophages. These prophages, which carry the genes for Shiga toxins, are present in Escherichia coli cells as silent elements until induction occurs. Mitomycin, along with UV light, is commonly used in laboratory settings to induce lambdoid prophages, leading to the activation of the genes responsible for Shiga toxin production. The induction of these prophages by mitomycin is part of a broader mechanism where various stressors, including antibiotics and oxidative stress, can lead to the activation of the genes encoding Shiga toxins in E. coli. This induction process is crucial for the efficient expression and subsequent production of Shiga toxins, contributing to the virulence of Shiga toxin-producing E. coli strains.
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24 Citations | Not addressed in the paper. |
| Mitomycin induces the production of Shiga toxin (Stx) by prophage induction in Shiga toxin-producing Escherichia coli (STEC) strains, as observed in the study on O26:H11 ST21 lineage. | |
| Mitomycin induces Shiga toxin production by triggering the host cell's SOS response to DNA damage, which activates lytic replication of Stx-phages carrying the Shiga toxin operon. | |
| Mitomycin induces Shiga toxin production by triggering lambdoid prophage induction, leading to efficient expression of Stx genes in Enterohemorrhagic Escherichia coli. | |
1 Citations | Not addressed in the paper. |
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