L
Ludger Johannes
Researcher at PSL Research University
Publications - 243
Citations - 18362
Ludger Johannes is an academic researcher from PSL Research University. The author has contributed to research in topics: Endosome & Golgi apparatus. The author has an hindex of 66, co-authored 225 publications receiving 16098 citations. Previous affiliations of Ludger Johannes include Centre national de la recherche scientifique & University of Paris.
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Journal ArticleDOI
Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
Bidisha Sinha,Darius Vasco Köster,Darius Vasco Köster,Richard Ruez,Richard Ruez,Pauline Gonnord,Pauline Gonnord,Michele Bastiani,Daniel Abankwa,Radu V. Stan,Gillian Butler-Browne,Benoît Vedie,Ludger Johannes,Ludger Johannes,Nobuhiro Morone,Robert G. Parton,Graça Raposo,Graça Raposo,Pierre Sens,Christophe Lamaze,Christophe Lamaze,Pierre Nassoy,Pierre Nassoy +22 more
TL;DR: Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress.
Journal ArticleDOI
Shiga toxin induces tubular membrane invaginations for its uptake into cells
Winfried Römer,Winfried Römer,Ludwig Berland,Valérie Chambon,Valérie Chambon,Katharina Gaus,Barbara Windschiegl,Danièle Tenza,Mohamed R. E. Aly,Vincent Fraisier,Jean-Claude Florent,David Perrais,Christophe Lamaze,Christophe Lamaze,Graça Raposo,Claudia Steinem,Pierre Sens,Patricia Bassereau,Ludger Johannes,Ludger Johannes +19 more
TL;DR: It is shown that the Gb3 (glycolipid)-binding B-subunit of bacterial Shiga toxin induces narrow tubular membrane invaginations in human and mouse cells and model membranes, and it is concluded that the B- subunit induces lipid reorganization that favours negative membrane curvature, which drives the formation of inward membrane tubules.
Journal ArticleDOI
Protein interaction mapping: A Drosophila case study
Etienne Formstecher,Sandra Aresta,Vincent Collura,Alexandre Hamburger,Alain Meil,Alexandra Trehin,Céline Reverdy,Virginie Betin,Sophie Maire,Christine Brun,Bernard Jacq,Monique Arpin,Yohanns Bellaïche,Saverio Bellusci,Philippe Benaroch,Michel Bornens,Roland Chanet,Philippe Chavrier,Olivier Delattre,Valérie Doye,Richard G. Fehon,Richard G. Fehon,Gérard Faye,Thierry Galli,Jean-Antoine Girault,Bruno Goud,Jean de Gunzburg,Ludger Johannes,Marie-Pierre Junier,Vincent Mirouse,Ashim Mukherjee,Dora Papadopoulo,Franck Perez,Anne Plessis,Carine Rossé,Simon Saule,Dominique Stoppa-Lyonnet,Alain Vincent,Michael A. White,Pierre Legrain,Jérôme Wojcik,Jacques Camonis,Jacques Camonis,Laurent Daviet +43 more
TL;DR: This work used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries.
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Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Romain Daillère,Romain Daillère,Romain Daillère,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Takahiro Yamazaki,Takahiro Yamazaki,Christophe Isnard,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Connie P.M. Duong,Connie P.M. Duong,Caroline Flament,Caroline Flament,Patricia Lepage,Maria Paula Roberti,Maria Paula Roberti,Bertrand Routy,Bertrand Routy,Bertrand Routy,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Lionel Apetoh,Lionel Apetoh,Sonia Becharef,Sonia Becharef,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Philippe Langella,Harry Sokol,Harry Sokol,Guido Kroemer,David Enot,Antoine Roux,Alexander M. M. Eggermont,Alexander M. M. Eggermont,Eric Tartour,Ludger Johannes,Ludger Johannes,Ludger Johannes,Paul Louis Woerther,Elisabeth Chachaty,Jean-Charles Soria,Jean-Charles Soria,Encouse B. Golden,Silvia C. Formenti,Magdalena Plebanski,Mutsa Tatenda Madondo,Philip Rosenstiel,Didier Raoult,Vincent Cattoir,Ivo G. Boneca,Mathias Chamaillard,Laurence Zitvogel +57 more
TL;DR: Enterococcus hirae and B. intestinihominis represent valuable "oncomicrobiotics" ameliorating the efficacy of the most common alkylating immunomodulatory compound CTX, and selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy.
Journal ArticleDOI
PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer
Cécile Badoual,Stéphane Hans,Nathalie Merillon,Cordelia Van Ryswick,Patrice Ravel,Nadine Benhamouda,Emeline Levionnois,Mevyn Nizard,Ali Si-Mohamed,Nicolas Besnier,Alain Gey,Rinat Rotem-Yehudar,Hélène Péré,Thi Tran,Coralie L. Guerin,Anne Chauvat,Estelle Dransart,Cécile Alanio,Sebastien Albert,Béatrix Barry,Federico Sandoval,Françoise Quintin-Colonna,Patrick Bruneval,Wolf H. Fridman,François M. Lemoine,Stéphane Oudard,Ludger Johannes,Daniel Olive,Daniel Brasnu,Eric Tartour +29 more
TL;DR: These findings prompt a need to revisit the significance of PD-1-infiltrating T cells in cancer, where it is suggested thatPD-1 detection may reflect a previous immune response against tumors that might be reactivated by PD- 1/PD-L1 blockade.