What is the role of BMPs in gastric cancer?
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Bone morphogenetic proteins (BMPs) play a multifaceted role in gastric cancer. BMP2 acts as a tumor suppressor by downregulating EZH2 and H3K27me3 through a non-SMAD BMP pathway, inhibiting cell proliferation . Conversely, BMP5 is reduced, while ACVRL1, ACVR1, TGFBR1, and BMPR2 are increased in gastric tumors, with BMPs and their receptors associated with poorer overall survival and promoting invasion, EMT, and stemness . BMP4 is frequently overexpressed in GC, correlating with poor prognosis, and promotes EMT and metastasis by upregulating ID1 expression . SOSTDC1 acts as a tumor suppressor by inhibiting c-Jun activation and promoting lung metastasis in GC . Additionally, BMP10 suppresses GC growth and migration by negatively regulating beta-catenin/TCF signaling . Overall, BMPs exhibit both tumor-suppressive and tumor-promoting functions in gastric cancer progression.
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| Papers (5) | Insight |
|---|---|
14 Citations | BMP10 inhibits growth and migration of gastric cancer cells, indicating a tumor-suppressive role of BMPs in gastric cancer progression. |
Open access•Journal Article 10 Citations | BMP antagonist SOSTDC1 restrains gastric cancer by inactivating c-Jun signaling, rather than canonical SMAD-dependent BMP pathway, highlighting a noncanonical BMP role in gastric cancer progression. |
13 Citations | BMP4 promotes gastric cancer metastasis by inducing EMT via upregulating ID1 expression. It plays a crucial role in EMT progression and metastasis in gastric cancer. |
12 Citations | BMPs in gastric cancer have dual roles: inhibiting proliferation but promoting invasion, EMT, and stemness. Elevated BMP receptor expression is linked to angiogenesis and lymphangiogenesis, aiding tumor progression. |
3 Citations | BMP2 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation through downregulating EZH2 and H3K27me3 via the non-SMAD BMP pathway, suggesting a potential therapeutic target. |
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