Xin Yuan Guan

TL;DR: Somatic as well as germline mutations of the gene were identified in RER+ tumor cells, and this mutS homolog is likely to be responsible for HNPCC.

TL;DR: Observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.

TL;DR: In this paper, the authors identify, isolate, and characterize the CSC population that drives and maintains hepatocellular carcinoma (HCC) growth and metastasis using a severe partial hepatectomy model.

TL;DR: The results indicate that unprocessed prelamin A and truncated lamin A act dominant negatively to perturb DNA damage response and repair, resulting in genomic instability which might contribute to laminopathy-based premature aging.

TL;DR: Comparing protein profiles between CD133+ and CD133− subpopulations isolated from Huh7 and PLC8024 and identifying aldehyde dehydrogenase 1A1 as one of the proteins that are preferentially expressed in theCD133+ subfraction reveals the existence of a hierarchical organization in HCC bearing tumorigenic potential in the order of CD133+.