What is the role of VP4 in the pathogenesis of IBDV infection?
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VP4, a viral protease encoded by Infectious Bursal Disease Virus (IBDV), plays crucial roles in the pathogenesis of IBDV infection. VP4 forms intracellular tubule-like structures during infection, potentially impacting host cell integrity and viral replication . Additionally, VP4 utilizes a Ser/Lys catalytic dyad mechanism for polyprotein processing, with phosphorylation at specific sites affecting its protease activity . Furthermore, differences in VP4 proteins from various IBDV strains influence the expression of anti-viral type I interferon and proinflammatory genes, impacting disease outcomes . Moreover, VP4 has been identified as an interferon suppressor by interacting with host cell proteins, leading to the suppression of type I interferon and facilitating viral growth . Overall, VP4's multifaceted functions in viral replication, host cell interactions, and immune response modulation highlight its significance in the pathogenesis of IBDV infection.
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| Papers (5) | Insight |
|---|---|
| VP4 of IBDV interacts with GILZ to suppress type I interferon, aiding in immunosuppression and enhancing IBDV growth in host cells, highlighting its crucial role in pathogenesis. | |
9 Citations | VP4 in IBDV infection acts as a phosphoprotein with phosphorylated residues Ser538, Tyr611, and Thr674, contributing to cleavage of precursor VP4-VP3 polyprotein, affecting serine-protease activity. |
| VP4 protein of IBDV strains influences pathogenesis by downregulating innate antiviral responses, particularly type I IFN, contributing to enhanced virulence of very virulent strains like UK661. | |
| The VP4 region in IBDV's polymerase plays a crucial role in viral replication and pathogenicity. Substitutions in this region can reduce pathogenicity but may not completely attenuate the virus. | |
7 Citations | VP4 in IBDV infection forms insoluble fibrils, reducing cytotoxicity, potentially preventing premature cell death, and facilitating viral replication by deforming host cell structures. |
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