What is the function of CCHFV OTU protease?
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The Crimean-Congo Hemorrhagic Fever Virus (CCHFV) OTU protease plays a crucial role in viral invasion and immune evasion. This protease is involved in antagonizing NF-κB signaling, suppressing the host's innate immune response by reversing post-translational modifications of ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15). The OTU domain within the CCHFV polymerase is essential for regulating viral replication by interacting with ISG15, impacting the polymerase activity. Inhibition of the CCHFV OTU protease has shown promise as a potential antiviral therapeutic target, with studies demonstrating the effectiveness of small molecules in inhibiting its activity. The protease's ability to interfere with host immune responses highlights its significance as a target for the development of antiviral interventions against CCHFV.
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| Papers (5) | Insight |
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2 Citations | The CCHFV vOTU protease functions to cleave and remove ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) from proteins, downregulating the host response by manipulating cellular signaling. |
| CCHFV OTU protease antagonizes NF-κB signaling, aiding viral invasion. It demonstrates deubiquitination activities, making it a potential target for antiviral therapeutics. | |
| The CCHFV OTU protease inhibits interferon production by deconjugating ubiquitin. Prolonged binding of a synthetic ubiquitin variant blocks viral infection by interfering with CCHFV RNA synthesis. | |
5 Citations | CCHFV OTU protease regulates polymerase activity by interacting with ISG15, compensating for the protease-inactive mutant, and influencing CCHFV replication without affecting IFN signaling. |
01 Nov 2020 2 Citations | CCHFV OTU protease suppresses innate immune response by reversing post-translational modifications by ubiquitin and ISG15, making it a potential therapeutic target for CCHFV. |
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