What molecular mechanisms underlie the modulation of tick host detection by bacterial infections?
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Tick-borne bacterial infections, such as Anaplasma phagocytophilum, modulate tick host detection through various molecular mechanisms. These mechanisms involve the manipulation of host protein content, proteolytic pathways, and tick salivary molecules. A. phagocytophilum selectively manipulates the levels of vertebrate host proteins in tick midguts and salivary glands, facilitating pathogen infection, multiplication, and transmission while preserving tick feeding and development . Tick sialome, which consists of bioactive molecules in tick saliva, plays a vital role in disarming host immunity and facilitating blood-feeding. Tick salivary molecules, including immunomodulatory and cement proteins, assist tick attachment, prolonged blood-feeding, and modulation of the host's immune responses . Tick hemocytes, responsible for cellular and humoral immunity, regulate microbial infection and pathogenesis. Phagocytic hemocytes eliminate bacterial infection, and their infection by Rickettsia parkeri modifies tick cellular immune responses . These molecular mechanisms provide insights into the complex interactions between tick-borne bacteria and tick hosts, which can be targeted for the development of effective control strategies, including vaccines and therapeutics .
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| The provided paper does not discuss the molecular mechanisms underlying the modulation of tick host detection by bacterial infections. The paper primarily focuses on the host immune responses to tick salivary components. | |
01 Jan 2019 | The provided paper does not specifically address the molecular mechanisms underlying the modulation of tick host detection by bacterial infections. |
| The provided paper does not specifically address the molecular mechanisms underlying the modulation of tick host detection by bacterial infections. | |
| The provided paper does not specifically discuss the molecular mechanisms underlying the modulation of tick host detection by bacterial infections. |
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