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The opening of Sites B results in an enhancement of the rate of uptake of nutrients; the resulting increase in the intracellular concentration of one or more of the nutrients starts the programmed operation of events that culminate in cell division; two possible mechanisms for the initiation of this programme are suggested.
These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function.
This reflects that cell growth and division are driven by energy or nutrition supply.
At the same time, conflicting evidence contradicts this view, indicating that cell division simply follows growth patterns that are dictated by the local availability of nutrients.
Taken together, the results suggest that the control of cell multiplication is intimately related to external concentrations of nutrients.
Ultimately this system may help to coordinate bacterial division with nutritional conditions to ensure the survival of newborn cells.
In the case of orthophosphate (Pi) or glucose, we have used this “nutrient concentration” method to demonstrate that under normal culture conditions, uptake of these nutrients is not a causal event in the regulation of cell division.
A combination of these factors, however, does not stimulate cell division under our conditions.
Mainly, cell division plays a more important role in the developmental phase of life than during vegetative growth.
Two functions--ion transport and cell growth--are closely connected and appear to be modulated by nutrients.

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