What role did genetic diversity and viral flow play in the evolution of SARS COV 2 variants?
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Genetic diversity and viral flow have played crucial roles in the evolution of SARS-CoV-2 variants. The genetic diversity observed in the virus has led to characteristics associated with increased transmission, resistance to antibodies, and potentially higher lethality . Studies have shown that mutations in the virus can be driven by both mutational bias and selection due to antagonistic pleiotropy, where certain mutations increase fitness at a cost to others . The genomic analysis of SARS-CoV-2 variants in Pakistan revealed multiple lineages circulating within the country, emphasizing the importance of monitoring nucleotide substitutions to understand evolutionary trends and implement effective control measures . Additionally, the episodic nature of viral diversity, characterized by sudden increases and collapses, suggests saltational evolution with epistasis, enabling the virus to rapidly evolve highly transmissible variants .
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| Papers (4) | Insight |
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| Genetic diversity and viral flow, influenced by host heterogeneity and epistasis, drove the punctuated evolution of SARS-CoV-2 variants, allowing for rapid emergence of highly transmissible strains. | |
| Genetic diversity and viral flow contributed to the evolution of multiple SARS-CoV-2 lineages in Pakistan, with dominant variants including Alpha, Beta, Delta, and Omicron, showing hypervariable spike gene regions. | |
| Genetic diversity and viral flow contributed to the evolution of SARS-CoV-2 variants, impacting transmission, antibody resistance, and potential lethality, emphasizing the need for continuous molecular surveillance and appropriate containment measures. | |
Journal Article | Genetic diversity in SARS-CoV-2, influenced by viral flow, drives variant evolution impacting transmission, antibody resistance, and potential lethality, necessitating continuous molecular surveillance for effective containment and response strategies. |
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