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Why would PRC1 complexes be in the euchromatin areas of the nucleus?

Chromosome conformation capture

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PRC1 complexes are found in euchromatin areas of the nucleus due to their role in mediating long-range interactions and facilitating developmental gene activation . These complexes play a crucial role in 3D genome organization by compacting local chromatin and clustering target loci at various length scales . The evolution of PRC1 complexes, including the expansion of the PCGF protein family, predates the bilaterian-cnidarian ancestor, indicating an early emergence of the genetic repertoire necessary for forming major vertebrate PRC1 complexes over 550 million years ago . Additionally, studies have shown that weak hydrophobic interactions between PRC1 molecules, characteristic of liquid-liquid phase separation, contribute to polycomb-mediated genome organization, further supporting their presence in euchromatin regions .

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Open access•Posted Content•DOI The genetic basis for PRC1 complex diversity emerged early in animal evolution James M Gahan, Fabian Rentzsch, Christine E. Schnitzler, Christine E. Schnitzler - Show less +3 more 20 Mar 2020-bioRxiv 11 Citations	PRC1 complexes are in euchromatin due to their role in gene silencing. The genetic basis for PRC1 diversity emerged early in animal evolution, influencing chromatin regulation.
Open access•Journal Article•DOI Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms Zhuangzhuang Geng, Zhonghua Gao, Zhonghua Gao - Show less +2 more 14 Nov 2020-International Journal of Molecular Sciences 33 Citations	PRC1 complexes can be found in euchromatin due to their role in transcription activation, long-range interactions, and diverse transcription regulation mechanisms, as highlighted in the paper.
Open access•Posted Content•DOI Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops Iain Williamson, Shelagh Boyle, Graeme R. Grimes, Elias T. Friman, Wendy A. Bickmore - Show less +4 more 22 Feb 2023-bioRxiv	PRC1 complexes are found in euchromatin due to their role in chromatin compaction and clustering of target loci, influencing genome organization through weak hydrophobic interactions and liquid-liquid phase separation.
Journal Article•DOI A ring of PRC1 interactions Eytan Zlotorynski 02 Jun 2020-Nature Reviews Molecular Cell Biology	A non-catalytic function of PRC1 facilitates chromatin interactions for developmental gene activation, suggesting PRC1 complexes in euchromatin areas may aid in this process.
Open access•Journal Article•DOI The genetic basis for PRC1 complex diversity emerged early in animal evolution. James M Gahan, Fabian Rentzsch, Christine E. Schnitzler - Show less +2 more 31 Aug 2020-Proceedings of the National Academy of Sciences of the United States of America 19 Citations	Not addressed in the paper.

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