scispace - formally typeset
Search or ask a question

Showing papers on "Addiction published in 1994"


Journal ArticleDOI
TL;DR: On February 25, 1994, the Food and Drug Administration (FDA) released a letter to the Coalition on Smoking or Health announcing its intention to consider regulating cigarettes.
Abstract: On February 25, 1994, the Food and Drug Administration (FDA) released a letter to the Coalition on Smoking or Health announcing its intention to consider regulating cigarettes. The agency's premises were that the vast majority of tobacco users self-administer the product for the drug effects of nicotine and to sustain addiction and that cigarette manufacturers control the levels of nicotine in cigarettes to maintain this addiction. The FDA further raised the possibility of regulating cigarettes on the basis of their nicotine content to prevent addiction. On February 28, 1994, the ABC news program Day One presented evidence that tobacco manufacturers . . .

460 citations


Journal ArticleDOI
Eric J. Nestler1
TL;DR: The purpose of this review is to illustrate the ways in which molecular neurobiological investigations will contribute to an improved understanding of drug addiction and, ultimately, to the development of more effective treatments.

295 citations


Journal ArticleDOI
TL;DR: Findings on gender differences from epidemiologic studies of completed and attempted suicides are presented, with a focus on suicide attempts among women, and possible reasons for gender differences in suicidal behaviors are discussed.

271 citations


Journal ArticleDOI
TL;DR: Initial psychometric tests show that the scale, developed to identify arcade video game addiction in adolescents, has acceptable internal consistency reliability and factorial validity, and is significantly related to alternative means of assessing excessive video game play.

250 citations


Journal ArticleDOI
TL;DR: In this paper, the authors explored the complex relationship between posttraumatic stress disorder and substance use disorders and found that women with PTSD were more likely to have been victims of sexual and physical abuse, particularly childhood abuse.
Abstract: To further explore the complex relationship between posttraumatic stress disorder (PISD) and substance use disorders, the authors compared 30 women with PTSD in substance abuse treatment with 25 women without PTSD in substance abuse treatment on degree of addiction severity, psychopa-thology, and aftercare compliance. Women with PTSD were more likely to have been victims of sexual and physical abuse, particularly childhood abuse. They had significantly higher scores on the Addiction Severity Index, were more likely to have comorbid affective disorder, and less likely to comply with aftercare. These results suggest that screening for victimization and PTSD among women presenting for substance abuse treatment may have important prognostic and treatment implications.

160 citations


Journal ArticleDOI
TL;DR: In this paper, the decision to quit smoking is treated as a choice under uncertainty in an empirical model that incorporates health, medical advice, addiction, and social interaction, and the results show a clear role for addiction, social interaction and current health status.

152 citations


Journal ArticleDOI
TL;DR: In this article, the authors explored the complex relationship between posttraumatic stress disorder (PTSD) and substance use disorders, and found that women with PTSD were more likely to have been victims of sexual and physical abuse, particularly childhood abuse.
Abstract: To further explore the complex relationship between posttraumatic stress disorder (PTSD) and substance use disorders, the authors compared 30 women with PTSD in substance abuse treatment with 25 women without PTSD in substance abuse treatment on degree of addiction severity, psychopathology, and aftercare compliance. Women with PTSD were more likely to have been victims of sexual and physical abuse, particularly childhood abuse. They had significantly higher scores on the Addiction Severity Index, were more likely to have comorbid affective disorder, and less likely to comply with aftercare. These results suggest that screening for victimization and PTSD among women presenting for substance abuse treatment may have important prognostic and treatment implications.

129 citations


Journal ArticleDOI
TL;DR: The critique focuses specifically on the evidence that many central nicotinic receptors, including those which mediate the effects of the drug on dopamine secretion, are readily desensitized by chronic exposure to agonist and that hypotheses which assume that nicotine inhaled from tobacco smoke invariably results in stimulation of the receptors must be treated with caution.
Abstract: There is little doubt that many habitual smokers find it difficult to quit the habit because they have become addicted to the nicotine present in the smoke. This paper addresses some of the pharmacological mechanisms underlying this addiction and discusses how an understanding of these mechanisms may contribute to the more effective use of nicotine replacement therapy during smoking cessation. It considers critically the evidence that the "rewarding" properties of nicotine, which serve to reinforce drug-seeking behaviour, are related to stimulation of the mesolimbic dopamine system of the brain. The critique focuses specifically on the evidence that many central nicotinic receptors, including those which mediate the effects of the drug on dopamine secretion, are readily desensitized by chronic exposure to agonist and that hypotheses which assume that nicotine inhaled from tobacco smoke invariably results in stimulation of the receptors must be treated with caution. Nicotinic receptors in the brain are, however, heterogeneous in nature with different molecular structures and pharmacologies. It is concluded that the reinforcing properties of nicotine sought by smokers may reflect both stimulation and desensitization of the different nicotinic receptor populations, and that smokers may adjust their smoking habits to achieve the balance of receptor stimulation and desensitization which they find most reinforcing. It seems likely that the efficacy of the different nicotine formulations during the treatment of smoking cessation may also reflect their ability to stimulate or desensitize brain nicotinic receptors.

124 citations


Book
01 Jan 1994
TL;DR: This book is a clear scientific account of the nature of addiction, stressing neurobiology and addictive behavior and describing the "highs" that drugs can produce.
Abstract: Drug addiction is a brain disease--that's the modern view and it is fully expressed in this up-to-date book. Among the many volumes on drugs written for lay readers, this one is unique in the breadth of its coverage and the depth of its science. The first part gives a clear scientific account of the nature of addiction, stressing neurobiology and addictive behavior and describing the "highs" that drugs can produce. The second section covers the seven families of addictive drugs, with emphasis on their actions in the brain and on psychological aspects: nicotine, alcohol, heroin and other opiates, cocaine and amphetamines, marijuana, caffeine, and hallucinogens like LSD. The third section deals with laws and drug control policies. Throughout, the author gives many interesting personal accounts of addiction research, to which he has highlighted new research on the genetics and neurobiology of susceptibility to addiction.

112 citations


Journal ArticleDOI
TL;DR: It is suggested that a class of compounds with partial agonist properties at the dopamine receptor may have therapeutic potential on the various phases of psychostimulant dependence.

111 citations


Book
01 Jan 1994
TL;DR: Students are exposed to both theory and practice through well designed models depicting diverse issues such as pain control, stress management, and addiction.
Abstract: Appropriate for any class that explores the psychosocial aspects of health and/or illness. Students are exposed to both theory and practice through well designed models depicting diverse issues such as pain control, stress management, and addiction.

Journal ArticleDOI
TL;DR: 50 subjects correctly classified the 25 items of the Work Addiction Risk Test by symptom, giving support for face validity.
Abstract: 50 subjects correctly classified the 25 items of the Work Addiction Risk Test by symptom, giving support for face validity.

Book
01 Jan 1994
TL;DR: Overview of Treatment Goals of Treatment Typologies of Addiction Assessment of the Patient Outcome research - Alcoholism Outcome Research - Drug Abuse Treatment of Patients for Specific Drugs of Abuse.
Abstract: Overview of Treatment Goals of Treatment Typologies of Addiction Assessment of the Patient Outcome Research - Alcoholism Outcome Research - Drug Abuse Treatment of Patients for Specific Drugs of Abuse Alcohol Cannabis Stimulants Hallucinogens Phencyclidine Tobacco Benzodiazepines and Other Sedative-Hypnotics Opioids - Detoxification Opioids - Methadone Maintenance Opioids - Antagonists and Partial Agonists Treatment Modalities Individual Treatment Psychodynamics Network Therapy for the Office Practitioner Individual Psychotherapy - Alcohol Individual Psychotherapy - Other Drugs Relapse Prevention Group and Family Treatment Group Therapy Family Therapy - Alcohol Family Therapy - Other Drugs Special Programmes Alcoholics Anonymous and Other 12-Step Groups In-Patient Treatment Employee Assistance Programmes Community-based treatment Therapeutic communities Adolescent substance Abuse Appendix - Psychoactive Substance Use Disorders, The American Psychiatric Association "Diagnostic and Statistical Manual of Mental Disorders", Fourth Edition

BookDOI
01 Jan 1994
TL;DR: Women and Alcohol: The Emergence of a Risk Group, B. Thom - The Police, Gender and the Culture of Drug Use and Addiction, M. Young - Symptoms, Struggles and Functions: What Does the Overdose Represent?
Abstract: Women and Alcohol: The Emergence of a Risk Group, B. Thom - The Police, Gender and the Culture of Drug Use and Addiction, M. Young - Symptoms, Struggles and Functions: What Does the Overdose Represent?, R. Littlewood - Whisky, Women and the Scottish Drink Problem, S. Macdonald - Gender, Ethnicity and Alcohol in the Former Soviet Union, T. Dragadze

Journal ArticleDOI
TL;DR: The DSM-III-R criteria for chemical dependency can be easily applied to sexual addiction as mentioned in this paper and the commonalities include obsession, denial, loss of control, compulsive behavior, continuation despite adverse consequences, and escalation of the behaviors.
Abstract: An ongoing controversy among addictionists is whether to accept “process” or behavioral addictions such as sexual addiction as within the scope of addiction medicine. This article delineates the controversy and reviews data that support the commonalities between behavioral and chemical dependencies. Similarities include obsession, denial, loss of control, compulsive behavior, continuation despite adverse consequences, and escalation of the behaviors. The DSM-III-R criteria for chemical dependency can be easily applied to sexual addiction. Another commonality is the refractoriness to treatment with traditional psychotherapeutic modalities versus the responsiveness to addiction treatment and 12-step mutual-help groups. Sexual addiction is of importance to addictionists because: 1) it is an addiction; 2) many chemically dependent patients are also addicted to sex and may relapse to chemical use because of untreated sex addiction; 3) sexual addiction contributes to the AIDS epidemic; and 4) compulsiv...

Journal ArticleDOI
TL;DR: Assessment of the relationship between sensation seeking and drug use in opiate addicts and their siblings in a cross-sectional family study found probands and their drug-abusing siblings showed greater sensation seeking than their non-drug-ABusing siblings and this diagnosis accounted for the most variance in regression models.
Abstract: Substance abuse and its correlative personality traits may have familial associations. We assessed the relationship between sensation seeking and drug use in 201 opiate addicts and 133 of their siblings in a cross-sectional family study. Probands and their drug-abusing siblings showed greater sensation seeking than their non-drug-abusing siblings and this diagnosis accounted for the most variance in regression models. Degree of sensation seeking correlated among drug-abusing siblings and with age of first drug use. The results are discussed in terms of substance abuse typologies and for using sensation-seeking assessments for prevention and treatment of substance abuse.

Journal ArticleDOI
TL;DR: The withdrawal syndrome has been carefully described and comprises physical and psychological features and generally starts 2-10 days after cessation of the benzodiazepine, depending on its elimination half-life.

Book
31 May 1994
TL;DR: Addiction - Misconduct and Disease Psychological Approaches to Addiction Initiation and Maintenance Dependence Change Prevention Postscript as mentioned in this paper, which is an extension of the work presented in this article.
Abstract: Addiction - Misconduct and Disease Psychological Approaches to Addiction Initiation and Maintenance Dependence Change Prevention Postscript.

Journal ArticleDOI
TL;DR: Drug withdrawal can be interpreted as a chronic pain condition that bridges the physical and emotional experiences of pain, especially regarding feelings of rejection, shame, inadequacy, and isolation, which suggests that AIDS education may need to address the notion of drug withdrawal and its effect on risk-taking behavior.
Abstract: This study shows that drug withdrawal can be interpreted as a chronic pain condition that bridges the physical and emotional experiences of pain, especially regarding feelings of rejection, shame, inadequacy, and isolation. The experience of withdrawal among drug users, both in treatment and actively using drugs, in a predominantly working-class, industrial Massachusetts city of 185,000 was studied through questionnaires, interviews, and ethnographic observation. The results suggest that the physical effects of drug use need to be explored as a symptom of a more extensive chronic condition in which pain is both the reason for and the consequence of drug addiction. This pain condition makes avoiding needle sharing and cleaning injection equipment with bleach difficult for many drug users because tolerance of withdrawal symptoms requires tolerating not only physical symptoms but also a more complex constellation of symptoms. This research suggests that AIDS education may need to address the notion of drug withdrawal and its effect on risk-taking behavior.

Journal ArticleDOI
TL;DR: In this article, the authors discuss the evolution of drug policy from biology to drug policy, and discuss the role of drugs in this process, and propose a framework for drug policy.
Abstract: (1994). Addiction: From Biology to Drug Policy. Journal of Psychoactive Drugs: Vol. 26, No. 1, pp. 89-91.

Journal ArticleDOI
01 Dec 1994
TL;DR: In elderly patients, awareness of coexistent diagnoses is essential in avoiding the inappropriate administration of multiple pharmaceutical agents and the possible risk of associated drug abuse and dependence.
Abstract: Objective To determine the prevalence of prescription drug dependence among elderly persons in an inpatient treatment setting, to identify apparent risk factors for drug dependence, and to ascertain what factors led to admission of these patients. Design We reviewed the medical records of 100 elderly patients dependent on prescription drugs who were admitted to the Mayo Inpatient Addiction Program between 1974 and 1993. Material and Methods Demographic features, chronic medical disorders, categories of substance dependence, diagnoses of mental disorders, and Minnesota Multiphasic Personality Inventory data were compiled and analyzed. Results The mean annual admissions rates for three substance use disorder groups among all elderly persons treated during the 20-year period of study were as follows: alcohol only, 72%; prescription drugs, 16%; and both alcohol and drugs, 12%. The group as a whole was socially intact. Female gender seemed to be a risk factor for drug dependence. By several measures, these elderly patients were characterized as a psychiatric population. The most frequent drug dependence involved sedatives or hypnotics. General medical data did not suggest that these elderly persons were more physically impaired than the general population. Conclusion In elderly patients, awareness of coexistent diagnoses is essential in avoiding the inappropriate administration of multiple pharmaceutical agents and the possible risk of associated drug abuse and dependence.

Journal ArticleDOI
TL;DR: Children of alcohol abusing parents (COAs) now receive more attention in their own right but data from methodologically sound studies is still thin and the strength of the association needs clarifying.
Abstract: Children of alcohol abusing parents (COAs) now receive more attention in their own right but data from methodologically sound studies is still thin. Genetic vulnerability increases risk of comorbidity for other psychiatric disorders and cognitive deficits as well as substance abuse. Neuropsychological effects of maternal alcohol consumption in pregnancy are more common than previously thought and paternal alcohol abuse may contribute to fetal damage. Family functioning is severely affected and COAs are at risk for child abuse though the strength of the association needs clarifying. Family drinking patterns are associated with teenage alcohol abuse and early induction increases the risk of addiction. COAs have raised morbidity rates for emotional and behavioural disturbance with impact on the developing child and separate prognostic significance for future adult morbidity other than alcoholism. Ethical considerations arise about the welfare of children cared for by alcohol abusing parents. Language: en

Journal ArticleDOI
TL;DR: Gambling cross addictions occur in both adults and adolescents and were almost exclusively a male condition, however, it must be noted only just over half of the responding agencies had encountered gambling cross addiction and reasons for this are speculated.
Abstract: A growing body of empirical and theoretical research has concentrated on the overlaps and commonalities among chemical and non-chemical (behavioural) addictions. Pathological gambling has perhaps been the most widely researched behavioural addiction and some of this research has concerned the co-existing links between pathological gambling and alcohol/drug addiction in both the gambling substance abuser and the substance abusing gambler (i.e. cross addiction). This study was of an exploratory nature and attempted to gather information and data regarding gambling cross addictions in the UK. To achieve this, 456 letters were sent to all drug and alcohol helping agencies in England requesting such information. This yielded 210 returns (46% response rate). Results indicated that gambling cross addictions occur in both adults and adolescents and were almost exclusively a male condition. However, it must be noted only just over half of the responding agencies had encountered gambling cross addiction and reasons for this are speculated. Results also indicated the existence of various cross addicted subgroups including an adolescent subgroup who were addicted to fruit machines and abused solvents. Future research ideas are also discussed.

Journal ArticleDOI
TL;DR: A dual pathway mechanism is proposed, in which the type of alcoholism of the parent plays a major role, and alcohol‐related expectancies are suggested to constitute a “final common pathway” between different risk factors and later alcohol abuse.
Abstract: The background and rationale of a recently started project of the Amsterdam Institute for Addiction Research are outlined. This project is aimed at the psychological mechanisms underlying an enhanced risk of (later) addiction in children of alcoholics and the relationship with childhood psychopathology. A dual pathway mechanism is proposed, in which the type of alcoholism of the parent plays a major role. The child of a multigenerational primary alcoholic parent may suffer from an inherited mild dysfunction of the prefrontal cortex, expressed in neuropsychological and personality characteristics similar to those of the alcoholic parent. These are impulsive, aggressive and reward-seeking behaviour, response perseveration and, in some children, related psychopathology such as conduct disorders. For a child of a secondary alcoholic parent, another mechanism is proposed. In these children, stress and social learning may lead to negative affectivity and repressive coping style, with emotional problems at a later age, and the risk of falling into the "circle of secondary alcoholism". In both pathways, alcohol-related expectancies are suggested to constitute a "final common pathway" between different risk factors and later alcohol abuse. Specific expectancies might be related to different pathways and to gender differences in later drinking patterns.

Journal Article
TL;DR: In this article, the early management and prevention of relapse of psychological and chemical addictions is discussed. And Cue exposure and stimulus control strategies may help these addictions, and the implications of these concepts for clinical practice and future research are commented upon.

Journal ArticleDOI
TL;DR: Part of the familial factor of alcoholism is associated with the existence of genetic vulnerability and genes coding for the second dopamine receptor, and these associations raise many questions, including how could dopamine be linked to alcoholism.


Journal ArticleDOI
TL;DR: The Masters and Johnson model of treatment combines this innovative trauma-based approach with a combination of cognitive, behavioral, and 12-step approaches in the treatment of sexual compulsivity.
Abstract: Serendipitously, the study of sexual abuse victims has resulted in a new understanding of paraphilia and sexual compulsivity. Frequently men and women who are sexually and physically abused present clinically with compulsive repetitive reenactment of early trauma in their sexual imagery and/or behavior. Utilizing a post-traumatic stress model, compulsive behavior is understood as a natural response to early trauma, which is later maintained by the association with release and pleasure, as well as becoming a habitual means of coping with stress. Comprehensive treatment requires a focus on completion of the cycle of original trauma and allowing and enabling direct expression of the intense affect embedded within these memories. The Masters and Johnson model of treatment combines this innovative trauma-based approach with a combination of cognitive, behavioral, and 12-step approaches in the treatment of sexual compulsivity. Providing a structured environment with eight hours of focused treatment dai...

Journal ArticleDOI
TL;DR: Content analysis of questionnaires from pediatric respondents indicated that pediatric nurses cared for cancer patients regularly but had poor understanding of general principles of pain management for the cancer patient, and hadpoor understanding of basic pharmacokinetic principles of common analgesic agents.

Journal ArticleDOI
TL;DR: Some potential barriers to effective parenting might include traumatic childhood histories, current relationship patterns, depression and low self-esteem, shame and guilt, and cognitive deficits.
Abstract: Although there is a growing literature on the characteristics of women with alcohol and drug addictions, and on the effects of prenatal exposure to drugs and alcohol, little is known about the mothering skills of alcohol or drug addicted women. The literature on alcohol and drug addiction and women is reviewed in order to propose characteristics that might affect parenting knowledge or skills. Some potential barriers to effective parenting might include traumatic childhood histories, current relationship patterns, depression and low self-esteem, shame and guilt, and cognitive deficits.