Showing papers on "Antitussive Agent published in 2006"

Phytotherapy of cough

Abstract: The problems emerging from the treatment of cough during many types of respiratory diseases by conventional opioid antitussive agents, such as codeine and codeine-like compounds, are well known. In recent years, much effort has been made to create drugs that exhibit minimum side effect on the organism. One of them is the medicinal plants, which are potential source of substances with high-antitussive efficiency with minimal unwanted effects. Recent trends of modern phytotherapy include specification of active substances responsible for therapeutic effect as well as their quantification in the healing drugs, which enables the treatment rationalization, especially the dosing and pursuing of adverse effects. The purpose of this chapter is to give the overview of some medicinal plants and their active compounds with cough-suppressing activity. The common information about antitussive efficiency of selected herbal products are replenished with results of our ongoing research program related to search for potentially antitussive active herbal polysaccharides.

Morphinan derivatives for use as antitussive agents

Abstract: Disclosed is an antitussive agent which is applicable to the treatment or prevention of cough. The antitussive agent comprises, as an active ingredient, a specific morphinan derivative having a nitrogenated cyclic substituent such as [N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy- morphinan-6β-yl)-3,4,5,6-tetarhydrophthalimide] shown by the formula below or a pharmacologically acceptable acid addition salt thereof. The antitussive agent has an excellent therapeutic or prophylactic effect on cough and produces little adverse side effects. [Chemical formula]

Interaction of papaverine with the enalapril-induced cough in guinea pig

Abstract: Background Angiotensin Converting Enzyme Inhibitors (ACEIs) like enalapril are extremely effective in the treatment of hypertension and heart failure. One of the most important side-effects of these drugs which can lead to cessation of therapy is a persistant dry cough, induced because of increased bradykinin levels in the lung. Although antitussive alkaloids like codeine are effective in suppressing this cough, they too present a wide range of side-effects, most notably addiction. Objective In a previous work we were able to show that noscapine, a non-narcotic antitussive agent, was able to decrease enalapril induced cough in guinea pigs. In this work, papaverine, another non-narcotic alkaloid found in opium latex was tested in the guinea pig model for antitussive activity. Method Cough was induced in enalapril pretreated guinea pigs by forcing the animals to inspire capsaicin aerosol in an air-tight chamber. Coughs were recorded in control animals and in those which had received different doses of papaverine. Characteristic changes in chamber air pressure, were detected by a pressure transducer. Results . At low doses (0.5 and 0.25 mg/kg) papaverine was able to decrease enalapril induced cough. CONCLUSION. This effect was not mediated by the action of the drug on mu receptors and was only observed in animals treated with enalapril.

Pharmacological treatments for sleep disorders

Abstract: This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or more antitussive agents. The antitussive agent or combination of antitussive agents can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoid receptor agonists, one or more serotonin reuptake inhibitors, a combination of reuptake inhibitors, other agents, or any combination of the foregoing.