Showing papers on "Chromosomal region published in 1970"
TL;DR: In this paper, it was shown that the chromosomal region from E. coli B approximately midway between the cysB and trp operons is the region responsible for the generation of the B-type deletions characteristically found in this strain.
65 citations
01 Jan 1970
TL;DR: On the basis of a series of cases of crossing-over a tentative map is proposed in which a linear order is presented for the genes or gene complexes which control the blood groups of this blood group system.
Abstract: In this report a series of cases of irregular transmission of blood groups of the system B in cattle will be presented. The irregularities are considered to be a result of crossing-over within the chromosomal region which controls this blood group system. On the basis of a series of cases of crossing-over a tentative map is proposed in which a linear order is presented for the genes or gene complexes which control the blood groups of this system.
28 citations
TL;DR: Two parental haplotypes occurred much oftener than should have been expected from the frequencies of the corresponding determinants, and there is thus linkage disequilibrium between the LA and Four series.
Abstract: Summary. A total of 973 unrelated Danes and Norwegians have been typed for a number of HL-A iso-antigens, and so have 150 Danish and Norwegian families with a total of 480 children. Two series of HL-A iso-antigens were investigated: the LA series with the antigens HL-Al, 2, 3, Ba*, ILN*and LA4, and the Four series with the antigens HL-A5, 7, 8, T12, R*, HN, FJH and BB. These antigens were inherited as co-dominant characters with the exception of Ba*, ILN*, and R*, which were operationally recessive to HL-A2, 3 and 5, respectively, but co-dominant in respect of the other factors. No individuals carried more than two antigens from each series, and the family analysis yielded no evidence against the assumption that the antigens within each series are controlled by mutually exclusive genetic determinants: The LA and Four series represent two mutational sites within the HL-A chromosomal region. No recombinations between these series were observed in this study, and the estimated upper limit of the recombination frequency between the corresponding sites was 0.84%. A total of 345 parental haplotypes could be unequivocally deduced; two of these, HL-A (1, 8) and HL-A (3, 7), occurred much oftener than should have been expected from the frequencies of the corresponding determinants, and there is thus linkage disequilibrium between the LA and Four series.
28 citations
TL;DR: Whilst studying the chromosomes of the peripheral blood lymphocytes of normal controls and patients with lymphoproliferative disorders, two examples of preferential breakage of a sensitive chromosomal region were found.
Abstract: Whilst studying the chromosomes of the peripheral blood lymphocytes of normal controls and patients with lymphoproliferative disorders, two examples of preferential breakage of a sensitive chromosomal region were found. A patient with lymphocytic lymphoma had a sensitive region in a C9 chromosome coinciding with the secondary constriction. A healthy woman had one A2 chromosome showing an unusually located secondary constriction in which breakage sometimes occurred.
27 citations
TL;DR: Genetic mapping of the E. coli chromosomal region carrying the structural gene (phoA) and the regulatory gene for alkaline phosphatase synthesis was carried out by conjugation and the genetic order lac phoA proC phoR tsx lon is proposed.
Abstract: Genetic mapping of the E. coli chromosomal region carrying the structural gene (phoA) and the regulatory gene (phoR) for alkaline phosphatase synthesis was carried out by conjugation. Recombinant colonies were selected and the segregation frequency of outside markers was determined. The genetic order lac phoA proC phoR tsx lon is proposed.
14 citations
TL;DR: Five patients with the same chromosome deletion and normal activities of TPI are reported, including a patient with a partial deletion of the short arm of chromosome 5 (cat cry syndrome), who were considered homozygous normal for the TPI gene.
Abstract: THE assignment of the gene for triosephosphate isomerase (TPI, EC 5.3.1.1) on the short arm of chromosome 5 (ref. 1) needs confirmation. Sparkes et al.1 reported diminished activities of TPI in the heterozygous range in a patient with a partial deletion of the short arm of chromosome 5 (cat cry syndrome). Both her parents, however, had normal values of this enzyme and were considered homozygous normal for the TPI gene. The authors concluded that the patient may have been hemizygous for TPI owing to loss of one TPI locus with the deleted chromosomal region. We now report data on five patients with the same chromosome deletion and normal activities of TPI.
5 citations