Showing papers on "Galangin published in 2001"
TL;DR: It is suggested that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects.
418 citations
TL;DR: Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals.
Abstract: Flavonoids are polyphenolic compounds that are present in plants. They have been shown to possess a variety of biological activities at non-toxic concentrations in organisms. Galangin, a member of the flavonol class of flavonoid, is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals. These activities will be discussed in this review. Based on our review, galangin may be a promising candidate for cancer chemoprevention.
200 citations
TL;DR: In this paper, the optimum temperature program was found for separation of reference samples of pinostrobin chalcone, pinocembrin, tectochrysin, genkwanin, chrysin and galangin, 5-hydroxy-4′,7-dimethoxyflavone.
Abstract: Between six and nine flavonoids have been identified by GC-MS in five samples of propolis and in one sample of bud exudate from poplar (Populus nigra), all collected in Poland. On the basis of experimental data and data obtained by use of Drylab software, the optimum temperature programme was found for separation of reference samples of pinostrobin chalcone, pinocembrin, tectochrysin, genkwanin, chrysin, galangin, 5-hydroxy-4′,7-dimethoxyflavone, and pilloin.
43 citations
TL;DR: Starting from the interaction of galangin (3,5,7-trihydroxyflavone) with a cytosolic nucleotide-binding domain of P-glycoprotein, a series of flavonol derivatives was synthesized and tested for their binding affinity towards the same target.
42 citations
TL;DR: The lipophilicity and toxicity of the four flavonols, galangin, kaempferol, quercetin and myrice-tin, which respectively have no, one, two and three hydroxyl groups on the B-ring, were compared to show that the cytotoxicity of myricetin was attributable to the hydrogen peroxide formed by autoxidation.
Abstract: We compared the lipophilicity and toxicity of the four flavonols, galangin, kaempferol, quercetin and myricetin, which respectively have no, one, two and three hydroxyl groups on the B-ring. The lipophilicity was in the order of myricetin < quercetin < kaempferol < galangin. The cytotoxicity determined by a colony-formation assay with Chinese hamster lung fibroblast V79 cells was in the order of quercetin < kaempferol < galangin < myricetin. Apart from myricetin, the order of lipophilicity was the same as that of cytotoxicity, implying that the cytotoxicity was attributable to the lipophilicity. The cytotoxicity of myricetin was attributable to the hydrogen peroxide formed by autoxidation.
41 citations
TL;DR: In this article, ten flavonoid compounds were isolated by means of preparative column chromatography from propolis collected in southern Poland and their mass spectra were compared with a spectrum library.
Abstract: Ten flavonoid compounds were isolated by means of preparative column chromatography from propolis collected in southern Poland. Their mass spectra were taken and compared with a spectrum library. As a result, nine of them were identified as: tectochrysin, pinocembrin, chrysin, galangin, genkwanin, apigenin, kaempferol, pilloin, 5-hydroxy-4′,7-dimethoxyflavone, and pinostrobin chalcone. Pilloin and pinostrobin chalcone were isolated from propolis for the first time. The optimum system of solvents for separation on a silica gel column was chosen on the basis on RF vs. mixed solvent composition dependence, obtained by means of thin-layer chromatography.
33 citations