Showing papers on "Iron response element published in 2013"

TL;DR: These results uncover separable physiological roles of each IRP and identify IRP1 as a therapeutic target for manipulating HIF-2α action in hematologic, oncologic, and other disorders.

TL;DR: It is suggested that IL-1β and TNF-α released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.

TL;DR: The expression of the four ferritin subunits were significantly elevated at the D-shaped stage and was relatively high in the adult mantle and hepatopancreas, and all four purified recombinant PyFers were able to inhibit the growth of the scallop pathogen Vibrio anguillarum.

TL;DR: Varying expression patterns indicate that two types of ferritins in H. schlegelii might play different roles in response to bacterial challenge, suggesting that HsFer-1 and Hs Fer-2 are likely to be functional proteins involved in immune defense against bacterial infection.

TL;DR: PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.