M
Matthias W. Hentze
Researcher at European Bioinformatics Institute
Publications - 332
Citations - 46237
Matthias W. Hentze is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 110, co-authored 319 publications receiving 41879 citations. Previous affiliations of Matthias W. Hentze include Molecular Medicine Partnership Unit & National Institutes of Health.
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Journal ArticleDOI
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Alfredo Castello,Bernd Fischer,Katrin Eichelbaum,Rastislav Horos,Benedikt M. Beckmann,Claudia Strein,Norman E. Davey,David T. Humphreys,Thomas Preiss,Thomas Preiss,Lars M. Steinmetz,Jeroen Krijgsveld,Matthias W. Hentze,Matthias W. Hentze +13 more
TL;DR: Unexpectedly, it is found that many proteins of the HeLa mRNA interactome are highly intrinsically disordered and enriched in short repetitive amino acid motifs.
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Balancing Acts: Molecular Control of Mammalian Iron Metabolism
TL;DR: The study of iron biology has provided novel insights into gene regulation and unveiled remarkable links to the immune system.
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Two to Tango: Regulation of Mammalian Iron Metabolism
TL;DR: How the two distinct systems of iron metabolism function and how they "tango" together in a coordinated manner are described are described.
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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
Andrew T. McKie,Paola Marciani,Andreas Rolfs,Karen Brennan,Kristina Wehr,Dalna Barrow,Silvia Miret,Adrian Bomford,Tim J Peters,Farzin Farzaneh,Matthias A. Hediger,Matthias W. Hentze,Robert J. Simpson +12 more
TL;DR: The isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells are described and it is concluded that IREG1 represents the long-sought duodental iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis.
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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Matthias W. Hentze,Lukas C. Kühn +1 more
TL;DR: The discovery of two IRE-regulated mRNAs encoding enzymes of the mitochondrial citric acid cycle may represent the beginnings of elucidating regulatory coupling between iron and energy metabolism, and IRP-1 has highlighted an unexpected role for iron sulfur clusters as post-translational regulatory switches.