Showing papers on "Keratan sulfate published in 1972"
TL;DR: The results indicate that the noncovalent interactions which are essential for the aggregation of proteoglycans do not require the presence of the chondroitin sulfate portion of the macromolecules.
157 citations
TL;DR: The data suggest that the core molecules contain a protein (or combination of proteins) with a molecular weight of about 200,000 to which different amounts of keratan sulfate are attached, and that polysaccharide molecules with larger molecular weights have higher ratios of glucosamine to galactosamine.
118 citations
TL;DR: Studies after further degradation indicate that glutamic acid (glutamine) could be a likely link between protein and keratan sulfate.
78 citations
TL;DR: Urinary MPS of children contain large amounts of a hyaluronidase-resistant, chondroitinase AC-susceptible compound whereas in adults this fraction is greatly diminished or absent, and children with a “marfanoid” syndrome gave positive CTAB screening tests but were within normal limits of MPS excretion.
43 citations
TL;DR: By this method, heparin, hyaluronic acid, keratan sulfate, and chondroitin sulfate were quantitatively determined from a mixture of six glycosaminoglycans.
42 citations
TL;DR: A comparison was made of the concentration and composition of the acidic glycosaminoglycans in human cornea, sclera and skin during five to nine months fetal development and in the adult.
Abstract: A comparison was made of the concentration and composition of the acidic glycosaminoglycans in human cornea, sclera and skin during five to nine months fetal development and in the adult. In skin, the concentration of the acidic glycosaminoglycans decreases gradually duringfetal development; the adult value is still less than the newborn; hyaluronic acid and dermatan sulfate are always present. In sclera, during the same period of development the concentration of the acidic glycosaminoglycans varied little; dermatan sulfate is the main component in both fetus and adult but the latter also contains some hyaluronic acid and chondroitin 4(6)-sulfate. The concentration of the acidic glycosaminoglycans in cornea increased by 33% at seven months gestation and remained constant; fetal cornea has chondroitin 4(6)-sulfate, chondroitin and a small amount of keratan sulfate (18 to 27% of the acidic glycosaminoglycans); in contrast, the adult cornea is rich in keratan sulfate (64 % of the acidic glycosaminoglycans) a...
40 citations
TL;DR: Excretions significantly higher than normal were found in 8 of 13 patients with Morquio's disease, but only four of these had striking increases, andOccasional values slightly above the normal range were associated with other pathology but in insufficient numbers to establish the significance.
10 citations
TL;DR: With increasing age, the concentration of C-4-S increased, C-6-S decreased and KS remained constant, and there was no variation when three different growth plate zones were sampled.
Abstract: Chondroitin-4-sulfate (C-4-S), chondroitin-6-sulfate (C-6-S) and keratan sulfate (KS) concentrations were measured in growth plate cartilage derived from rabbits of two different ages, and from three growth plate zones from rabbits of the same age. With increasing age, the concentration of C-4-S increased, C-6-S decreased and KS remained constant. There was no variation when three different growth plate zones were sampled. Radiosulfate uptake into chondroitan sulfate was also measured, and this showed an inverse relationship to concentration with increasing age.
6 citations