Showing papers on "Morphogen published in 1987"
TL;DR: Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors and Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
Abstract: Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
1,952 citations
TL;DR: DIF-1, the major bioactive species after purification, has now been identified using a combined microchemical, spectroscopic and synthetic approach and represents a new class of effector molecule.
Abstract: Morphogens are signal molecules presumed to exist in embryos and to be involved in establishing the spatial pattern of cells during development. Differentiation inducing factor (DIF) has the properties of a morphogen required for producing the prestalk/prespore pattern in the aggregate formed by cells of the slime mould Dictyostelium in response to starvation. DIF-1, the major bioactive species after purification, has now been identified using a combined microchemical, spectroscopic and synthetic approach. The structure is defined as 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, and represents a new class of effector molecule. The availability of relatively large quantities of synthetic and isotopically labelled materials should now allow progress towards a detailed understanding of the pattern-forming processes in Dictyostelium development.
348 citations
TL;DR: The demonstration that DIF induces a gene normally only expressed in the prestalk zone of the slug provides strong evidence that Dif is a Dictyostelium morphogen.
202 citations