Showing papers on "Mucinous tubular and spindle cell carcinoma published in 2014"
TL;DR: Clinical, morphological and genetic features of new disease entities such as acquired cystic disease-associated RCC, clear cell papillary RCC and renal carcinoma with t(6;11)(p21:q12) have been discovered are introduced.
Abstract: The recent classification of renal tumors is based on genetic evidence as well as on histologic features. Malignant tumor includes clear cell renal carcinoma (RCC), multilocular cystic RCC, papillary RCC, chromophobe RCC, carcinoma of the collecting duct of Bellini, renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions and mucinous tubular and spindle cell carcinoma. Benign tumor is subdivided into papillary adenoma, renal oncocytoma and metanephric adenoma. Recently, new disease entities such as acquired cystic disease-associated RCC, clear cell papillary RCC and renal carcinoma with t(6;11)(p21:q12) have been discovered. In this article, we briefly review and introduce the clinical, morphological and genetic features of these tumor entities.
21 citations
TL;DR: A challenging case MTSCC with a peculiar morphology in a 42-year-old man, arising in a background of end-stage renal disease (ESRD), supported the diagnosis of M TSCC and the ultrastructural profile was not entirely indicative of the cellular origin of the tumor.
Abstract: Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of kidney tumor with relatively indolent behavior. Non-classic morphological variants have not been well studied and rarely been reported. We report a challenging case MTSCC with a peculiar morphology in a 42-year-old man, arising in a background of end-stage renal disease (ESRD). Predominant areas with extensive papillary architecture, psammoma bodies and stromal macrophageal aggregates, reminiscent of a papillary renal cell carcinoma (papillary RCC), were intermixed with foci that transitioned into a MTSCC-like morphology exhibiting elongated tubules and a low grade spindle cell component in a background of mucinous stroma. Immunohistochemistry demonstrated diffuse positivity for P504s/AMACR and vimentin in tumor cells. Focal positivity for RCC, CD10 and CK7 was also noted. Kidney-specific cadherin, cytokeratin 34betaE12 and TFE3 stains were negative in the tumor. The major differential diagnostic considerations were papillary RCC, clear cell papillary RCC, and Xp11.2 translocation carcinoma. Negative FISH studies for trisomy 7 and 17 in both papillary and spindled components supported the diagnosis of MTSCC. The ultrastructural profile was not entirely indicative of the cellular origin of the tumor. Cytogenetic analysis should be performed in atypical cases of MTSCC for precise diagnosis.
16 citations
TL;DR: The MTSCC-K is a low-grade polymorphic renal epithelial neoplasm, which may be diagnosed by immunohistochemistry and the patients are likely to have an improved prognosis following surgery compared with patients with other renal cell carcinomas.
Abstract: Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) is an unusual renal tumor. It is important to increase the recognition of MTSCC-K and improve the level of clinical diagnosis. The current study presents a case of MTSCC-K with clinical, imaging and pathological examination. A 60-year-old female presented to the First Hospital of Jilin University suffering from lumbodorsalgia on the right side for approximately one month, without gross hematuria and fever. Imaging examination by abdominal computed tomography scan revealed a ~6.5×5.0-cm solid mass in the inferior pole of the right kidney. The patient underwent laparoscopic radical resection of the right kidney. Pathological examination showed that the tumor was composed of small, elongated cords or tubules, in a tightly packed arrangement. Myxoid stroma was shown to be interspersed among the tubular cells, and appeared to exhibit slender tubular spindle cell-like structures. Tumor cells were smaller and cube-shaped or oval, with single small eosinophilic nucleoli and low-grade nuclei. Occasionally, necrosis and foam cell infiltration were observed. Myxoid stroma was stained by acidic mucus. Immunohistochemical markers, including CK7, CK19, EMA, Vimentin and P504S (AMACR) showed positive expression in tumoral cells, but the tumoral cells were CD10-negative. The MTSCC-K is a low-grade polymorphic renal epithelial neoplasm, which may be diagnosed by immunohistochemistry. The patients are likely to have an improved prognosis following surgery compared with patients with other renal cell carcinomas.
11 citations
TL;DR: It was found that morphologic and immunophenotyping features showed more overlap between MTSC and sPRCC and gains of chromosomes 7 and 17 and loss of Y, which are characteristic of PRCC were observed in two cases of s PRCC and one case of MTSS, suggesting that MTSc is similar to sPR CC or may be a subtype of PR CC.
Abstract: Mucinous tubular and spindle cell carcinoma (MTSC) was first recognized as a specific entity in the World Health Organization 2004 classification. The “classic” tumor presentation includes an extracellular blue-gray mucinous/myxoid matrix accompanying the typical tubular and spindle cell epithelial components. Tubules are lined by cuboidal to columnar cells with bland nuclei, central small to medium sized nucleoli, and few to no mitoses. By expanding the histologic spectrum, a number of studies highlighted the distinction between MTSC and solid variant of papillary renal cell carcinoma (sPRCC), although controversy still exists. Here, we evaluated two cases of MTSC and compared two cases of sPRCC by light microscopy, special staining, immunohistochemical staining and fluorescence in situ hybridization (FISH). We found that morphologic and immunophenotyping features showed more overlap between MTSC and sPRCC. In addition, gains of chromosomes 7 and 17 and loss of Y, which are characteristic of PRCC, were observed in two cases of sPRCC and one case of MTSC, suggesting that MTSC is similar to sPRCC or may be a subtype of PRCC. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_194
10 citations
Journal Article•
TL;DR: MTSCC tends to be a solitary, isodense mass with poorly defined margin arising from the renal medulla with enhancement less than the cortex and medulla during all phases.
Abstract: BACKGROUND There are relatively few reports focusing on clinical and multi-slice CT (MSCT) imaging findings of mucinous tubular and spindle cell carcinoma (MTSCC). Our study aimed to characterize the clinical and MSCT imaging features of MTSCC. METHODS The imaging findings in 17 patients with MTSCC by MSCT were retrospectively studied. MSCT was undertaken to investigate tumor location, size, density, cystic or solid appearance, calcification, capsule sign, enhancement pattern, and retroperitoneal lymph node metastasis. RESULTS Tumors (mean diameter, (3.9 ± 1.7) cm) were solitary (17/17), solid (16/17) with cystic components (5/17), had no calcifications (14/17), had a poorly defined margin (14/17), were centered in the medulla (15/17), compressed the renal pelvis (7/17), and neither lymph node nor distant metastasis was found. The attenuation of MTSCC tumors was equal to that of the renal cortex or medulla on unenhanced CT (32.3 ± 2.6, 36.3 ± 4.6, 33.2 ± 3.9, respectively, P > 0.05), while tumor enhancement after administration of a contrast agent was lower than that of normal renal cortex and medulla during all phases (P < 0.05). CONCLUSION MTSCC tends to be a solitary, isodense mass with poorly defined margin arising from the renal medulla with enhancement less than the cortex and medulla during all phases.
9 citations
TL;DR: The CEUS and CECT findings of MTSCC were generally hypov vascular and needed to be distinguished from other hypovascular renal tumours.
Abstract: To report the features of contrast-enhanced ultrasonography (CEUS) and computer tomography (CECT) of mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney. Six cases of MTSCC of the kidney were studied, and the literature was reviewed. Ultrasonography, CEUS, and CECT examinations were routinely performed before the operation. Histological analysis, including HE staining and immunohistochemistry, was performed with the envision method. The age of the patients ranged from 48 to 75 years (mean 55.5 years). One patient was male, and five were females. All six tumours exhibited an admixture of tubules, spindle cells, and mucinous stroma in variable proportions. CEUS and CECT showed enhancement of the lesions, but the enhancement was less than the adjacent renal parenchyma, leading to the diagnosis of hypovascular renal tumours. All patients were alive and well at the follow-up time of 17–73 months (mean 39.5 months) with CEUS and/or CECT at 3 months, 6 months, and 1 year and then annually thereafter following surgery. No metastases were detected. The CEUS and CECT findings of MTSCC were generally hypovascular and needed to be distinguished from other hypovascular renal tumours.
5 citations
Journal Article•
TL;DR: Case 1 carries the longest disease-free survival reported in literature since MTSCC was defined and ranks the oldest since reported in Literature, while Case 2 is the first report of "mucin-poor" MTS CC associated with simultaneous conventional clear cell RCC.
Abstract: Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare and recently recognized subtype of renal cell carcinoma (RCC). Apart from the classic morphology comprising conventional three components, there exist a large number of non-classic morphological variants of MTSCC, which make it necessity to differentiate from other RCC. Herein, we report two non-classic morphological variants of MTSCC. Case 1, a 85 years old man, showed numerous vacuoles among inherent components and cytoplasmic pallor/clearing within tubules mimicking conventional clear cell RCC with a 8.5 years follow-up, while Case 2 indicated a “mucin-poor” MTSCC associated with simultaneous conventional clear cell RCC at her age of 73 years. Until now Case 1 carries the longest disease-free survival reported in literature since MTSCC was defined and ranks the oldest since reported in literature, while Case 2 is the first report of “mucin-poor” MTSCC associated with simultaneous conventional clear cell RCC. Now, since no biomarkers or imagining tools but pathological examination can confirm the diagnosis of MTSCC, the management is always following the guideline of RCC in clinical practice. Generally, most reports consider it as a good prognosis disease, but sarcomatoid variant, even classic subtype can progress rapidly to life-threatening disease.
5 citations
TL;DR: Two cases of mucinous tubular and spindle cell carcinoma of the kidney are reported in which contrast‐enhanced ultrasound was used.
Abstract: Mucinous tubular and spindle cell carcinoma of the kidney is a relatively rare pathologic entity that has recently been described in the World Health Organization 2004 renal cell carcinoma classification. We report two cases of mucinous tubular and spindle cell carcinoma in which contrast-enhanced ultrasound was used. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:55–58, 2015
4 citations
TL;DR: Mucinous tubular and spindle cell carcinoma is generally a low grade tumor associated with good prognosis and its definitive treatment is surgical excision.
2 citations
TL;DR: A 27-year-old women requesting assistance for an unspecified abdominal pain localized in the right flank that worsened after a recent delivery was discovered to have a solid mass in the upper pole of her right kidney, the first case of this disease discovered during pregnancy or puerperium.
Abstract: A 27-year-old women requesting assistance for an unspecified abdominal pain localized in the right flank that worsened after a recent delivery was discovered to have a solid mass in the upper pole of her right kidney. Radiological findings showed benign characteristics but without a clear diagnosis. Subsequently, a laparotomic nephron-sparing enucleation of a solid, encapsulated, brownish-white mass, localized in the cortical portion of the upper kidney pole, was performed. Pathological examination of the specimen showed a rare mucinous tubular and spindle cell carcinoma with an almost total mucinous component. To our knowledge, this is the first case of this disease discovered during pregnancy or puerperium. A multidisciplinary approach should be mandatory in order to correctly recognize and treat such a rare disease and to avoid administration of excessive adjuvant treatment to patients with a low-grade malignancy during pregnancy or puerperium.
1 citations
TL;DR: キーワード: 〈要旨〉 長期透析患者に発生した粘液管状紡錘細胞癌の 1例を経験したので報告する.
Abstract: キーワード:長期透析,粘液管状紡錘細胞癌 〈要旨〉 長期透析患者に発生した粘液管状紡錘細胞癌の 1例を経験したので報告する.患者は 65歳男性,1999年に糖尿病 性腎症で血液透析導入.2013年 4月から肉眼的血尿が出現し 10月の定期 CTにて左腎腫瘍を指摘され当科紹介. CTでは左腎臓に 65 mmの腫瘤を認め,傍大動脈リンパ節腫大も認めた.左腎細胞癌(cT1bN2M0)と診断し根治 的左腎摘除術およびリンパ節郭清術を施行.肉眼的に腫瘍の境界は明瞭で割面は黄褐色調であった.組織学的に異 型性の顕著な腫瘍細胞が管状~乳頭状構造を呈して浸潤性に増殖しており紡錘形細胞も混在していた.免疫組織学 的には CK7(+),CK34βE12(-),vimentin(+),CD10(+),P504S(+),TFE3(-),CA9(-)であり,Alcian blue染色で間質が陽性であった.以上から粘液管状紡錘細胞癌と診断した.現在術後 6か月経過するが再発なく生 存中である.