Qing Zhang

TL;DR: Evidence is provided that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes, forming a transcriptional complex whose activity is inhibited by Hpo signaling.

TL;DR: Evidence is provided that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development, and inactivating HIB results in Ci accumulation and enhanced pathway activity.

TL;DR: It is shown that Double-time (DBT)/CKIe and CKIα act in conjunction to promote Ci processing and it is proposed that phosphorylation of Ci by CKI creates multiple Slimb/β-TRCP binding sites that act cooperatively to recruit SCF Slimb-TR CP.

TL;DR: This work demonstrates that SPOP, functioning as an E3 ubiquitin ligase substrate-binding protein, promotes ubiquitination and proteasome degradation of wild-type ERG by recognizing a degron motif at the N terminus of ERG and suggests that overcoming ERG resistance to SPOP-mediated degradation represents a viable strategy for treatment of prostate cancer.

TL;DR: Self-assembled tumor-targeting hyaluronic acid-IR-780 nanoparticles for photothermal ablation in over-expressing CD44 (the receptor for HA) bladder cancer are developed, which show high tumor selectivity, high treatment efficacy, good bioavailability, and excellent biocompatibility.