Showing papers on "Perspective (graphical) published in 1973"
TL;DR: A general overview of protein-small-molecule binding should cover the following aspects of such interactions: 1. stoichiometry; 2. energetics; 3. molecular nature; 4 dynamics; and 5 . biological function.
Abstract: Protein-drug binding is, in essence, an interaction between a biological macromolecule and a small molecule. This type of complexation is only one of many different types of protein interaction, all of which are molecularly intertwined in a cellular or organ environment. In a general perspective, it is convenient to view such interactions as falling into two broad categories (FIGURE 1 ) , intramolecular and intermolecular. Intramolecular interactions are manifested in the different conformations that may coexist for a particular species of protein. Intermolecular complexes may be further subdivided into two classes (FIGURE 1 ), those with small molecules and those with other macromolecules. Included among the latter are the quaternary structures constituted of identical subunits, in addition to heteromeric ensembles of various types, for example, protein-protein, protein-nucleic acid. These interactions are the foundation of an interlocked set of macromolecular dynamic rearrangements that provide the fine modulation within and between parts of an organism. Small-molecule binding plays a crucial role in this manifold because it usually provides the molecular coupling device for interlinking the macromolecular states and for adjusting their relative concentrations. A general overview of protein-small-molecule binding should cover the following aspects of such interactions: 1. stoichiometry; 2. energetics; 3. molecular nature; 4. dynamics; and 5 . biological function. This brief review will describe a few representative studies from these topics to illustrate some of the general principles that govern macromolecule-minimolecule interactions.
201 citations
01 Jan 1973
200 citations
TL;DR: A Theory of Justice as mentioned in this paper is one of the most important works of political philosophy, and it has attracted a great deal of attention in the last few decades. But it has not yet received, in any of the vast number of articles on and reviews of the book which have been published, detailed attention which it deserves.
Abstract: No book of political philosophy since I read the great classics of the subject has stirred my thoughts as deeply as John Rawls's A Theory of Justice. But I shall not in this article offer a general assessment of this important and most interesting work. I shall be concerned with only one of its themes, namely, Rawls's account of the relationship between justice and liberty, and in particular with his conception that justice requires that liberty may only be limited for the sake of liberty and not for the sake of other social and economic advantages. I have chosen this theme partly because of its obvious importance to lawyers who are, as it were, professionally concerned with limitations of liberty and with the justice or injustice of such limitations. I choose this theme also because this part of Rawls's book has not, I think, so far received, in any of the vast number of articles on and reviews of the book which have been published, the detailed attention which it deserves. Yet, as Sidgwick found when he considered a somewhat similar doctrine ascribing priority to liberty over other values, such a conception of liberty, though undoubtedly striking a responsive chord in the heart of any liberal, has its baffling as well as its attractive aspect,' which becomes apparent when we consider, as Rawls intends that we should, what the application of this doctrine would require in practice. Part of what follows is concerned with a major question of interpretation of Rawls's doctrine and the rest is critical. But I am very conscious that I may have failed to keep constantly in view or in proper perspective all the arguments which Rawls, at different places in this long and complex work, concentrates on the points which I find unconvincing. I would not therefore be surprised if my iinterpretation could be corrected and my criticisms answered by some further explanation which the author could supply. Indeed I do not write to confute, but mainly in the hope that in some of the innumerable future
172 citations
TL;DR: In this paper, the authors make a commitment to a new point of view in the life-space of people by making help available when and where it is needed in the space of people.
Abstract: Services that make help available when and where it is needed in the life-space of people represent a beginning commitment to a new point of view
131 citations
115 citations
Book•
01 Jan 1973
TL;DR: This book shows the new habit that, actually it's a very old habit to do that can make your life more qualified and change your habit to hang or waste the time to only chat with your friends.
Abstract: Change your habit to hang or waste the time to only chat with your friends. It is done by your everyday, don't you feel bored? Now, we will show you the new habit that, actually it's a very old habit to do that can make your life more qualified. When feeling bored of always chatting with your friends all free time, you can find the book enPDF nursing in society a historical perspective and then read it.
69 citations
53 citations
TL;DR: A General Systems and Role Theory Perspective for Social Organization is presented in this article, where a general system and role theory perspective is used to analyze the role of social organizations in social organization.
Abstract: Social Organization :A General Systems and Role Theory Perspective , Social Organization :A General Systems and Role Theory Perspective , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
46 citations
TL;DR: Motivation theory has been traced from its inception in Aristotle's thinking to the form it has assumed in contemporary work as discussed by the authors, where mental images of goal objects serve as motives by providing energization and direction.
Abstract: An extremely influential theory of motivation is traced from its inception in Aristotle's thinking to the form it has assumed in contemporary work. The ancient theory--that mental images of goal objects serve as motives by providing energization and direction - seemed to succumb to the Darwinian revolution in the nineteenth century, despite William James' attempt to save it, but then surreptitiously reappeared in behavioristic systems and has since openly surfaced in Mowrer's theory. Its treatment in contemporary physiological and cognitive psychology obviates the problems that led to its earlier abandonment.
Journal Article•
TL;DR: Modern adolescent runaways reflect varying family dynamics, as revealed through long-term family therapy and observation, which can be conceptualized as disturbances in transactional modes.
Abstract: Modern adolescent runaways reflect varying family dynamics, as revealed through long-term family therapy and observation. These family dynamics can be conceptualized as disturbances in transactional modes. Transactional modes operate as the covert organizing background to the more overt and specific child-parent interactions. The modes of binding, delegating, and expelling are defined. Depending on which mode is dominant, runaways and their families need to be viewed and treated differently.
Book•
01 Jan 1973
TL;DR: A Computer Perspective as mentioned in this paper is an illustrated essay on the origins and first lines of development of the computer, which is based on an exhibition conceived and assembled for International Business Machines Corporation.
Abstract: A Computer Perspective is an illustrated essay on the origins and first lines of development of the computer. The complex network of creative forces and social pressures that have produced the computer is personified here in the creators of instruments of computation, and their machines or tables; the inventors of mathematical or logical concepts and their applications; and the fabricators of practical devices to serve the immediate needs of government, commerce, engineering, and science. The book is based on an exhibition conceived and assembled for International Business Machines Corporation. Like the exhibition, it is not a history in the narrow sense of a chronology of concepts and devices. Yet these pages actually display more true history (in relation to the computer) than many more conventional presentations of the development of science and technology.
TL;DR: In this paper, a review amends earlier reviews of imitation theory and research (e.g., Flanders, 1968) in which one important perspective is omitted, which has its basis in the work of Pia.
Abstract: This review amends earlier reviews of imitation theory and research (e.g., Flanders, 1968) in which one important perspective is omitted. According to this view, which has its basis in the work of Pia
TL;DR: In this paper, the author describes the feeling of being trapped in a great traffic jam and feeling as though the jam is moving toward the Hill where Congress sits in judgment on all the administrative agencies of the Government.
Abstract: Sometimes when I get home at night in Washington I feel as though I had been in a great traffic jam. The jam is moving toward the Hill where Congress sits in judgment on all the administrative agencies of the Government. In that traffic jam are all kinds of vehicles ... There are all kinds of conveyances, for example, that the Army can put into the street—tanks, gun carriages, trucks ... There are the hayricks and the hinders and the ploughs and all the other things that the Department of Agriculture manages to put into the streets ... the handsome limousines in which the Department of Commerce rides ... the barouches in which the Department of State rides in such dignity. It seems to me as I stand on the sidewalk watching it become more congested and more difficult, and then because the responsibility is mine and I must, I take a very firm hold on the handles of the baby carriage and I wheel it into the traffic.
TL;DR: The authors examined changing Chinese attitudes to their place in the world from a Chinese historical and intellectual perspective, in order to provide a basis for anticipating developments in the future attuned more to a Chinese than to a western point of view.
Abstract: The object of this article is to examine changing Chinese attitudes to their place in the world from a Chinese historical and intellectual perspective, in order to provide a basis for anticipating developments in the future attuned more to a Chinese than to a western point of view. The question immediately arises whether such a perspective is in any way relevant to the recent theory and practice of international relations in the People's Republic of China, and what insights, if any, such a perspective may provide for discussing the future. This is a controversial subject concerned with the nature of cultural change, and the extent to which " imprinting" from a long continuity of accepted social and cultural values can psychologically condition people even after a decisive break in that tradition appears to have occurred.
TL;DR: In this article, the centralizationdecentralization dilemma is discussed and different approaches to understand the concept are critically reviewed, and then Walker's (1972) contribution is used as a springboard to provide another perspective which hopefully will lead to clearer definition and understanding.
Abstract: A major task confronting any discipline is the clarification of concepts which are considered basic to its theoretical and conceptual frameworks. This paper attempts to pursue the centralizationdecentralization dilemma. A setting for this discussion is provided by noting some of the uses of terminology, followed by a consideration of inherent difficulties in conceptualizing. Different approaches to understanding the concept are critically reviewed, and then Walker's (1972) contribution is used as a springboard to provide another perspective which hopefully will lead to clearer definition and understanding.