Showing papers on "Sterculia foetida published in 2016"

Development and evaluation of ofloxacin floating tablets using natural polymer: sterculia foetida linn. gum

Abstract: Objective: The aim of the present work was to develop a gastro retentive drug delivery system of Ofloxacin with the objective of retarding the drug release when the dosage form is exposed to gastrointestinal fluid. Methods: Floating tablets of Ofloxacin were developed using a natural gum like Sterculia foetida. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in vitro buoyancy, in vitro drug release and release order kinetics. The formulations were optimized for different concentrations of Sterculia foetida . Results: The results of in vitro release studies showed that optimized formulation (F4) could sustain drug release (97.86%) for 24 h and remain buoyant for 24 h. The optimized formulation was subjected to various release kinetic investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation. Conclusion: Floating tablets of Ofloxacin were successfully formulated with the ability of providing controlled release and non-Fickian transport of the drug from tablets was confirmed. Keywords: Ofloxacin, Floating drug delivery system, Sterculia foetida , Buoyancy

Development of functionalized heterogeneous catalyst from Ceiba pentandra stalk for biodiesel production using Sterculia foetida seed oil

Abstract: An attempt is made to develop a new carbon-based solid acid catalyst, processed through sulfonation of carbonized Ceiba pentandra stalks. C. pentandra catalyzes Sterculia foetida oil through esterification and transesterification simultaneously. Physical and chemical characteristics of this novel catalyst had been analyzed by a range of strategies like Scanning Electron Microscope, Fourier Infrared Spectroscopy, and X-ray diffraction. During the optimization study, an optimal yield of 97 wt % was obtained using 18:1 methanol to oil molar ratio, 3.5 wt % catalyst concentration and reaction temperature of 498 K. The fuel properties of the produced biodiesel were evaluated and compared with ASTM D6751 biodiesel standard. © 2015 American Institute of Chemical Engineers Environ Prog, 2015

Synthesis, characterization and evaluation of antiproliferative activity of diisopropylphenyl esters of fatty acids from selected oils

Abstract: The present investigation describes the synthesis, characterization and evaluation of antiproliferative activity of novel diisopropylphenol (propofol) conjugates of fatty acids. The fatty acids were obtained from oils of Jatropha curcas (jatropha) and Pongamia glabra (karanja) containing unsaturated-rich fatty acids, Sterculia foetida (containing cyclopropene-rich fatty acids), Samia cynthia (eri pupae, containing polyunsaturated-rich fatty acid, 18:3) and Cocos nucifera (coconut, containing medium-chain saturated-rich fatty acids). The synthesized conjugates viz. propofol-jatropha mixed fatty acid conjugates (2,4P-JTA and 2,6P-JTA), propofol-karanja mixed fatty acid conjugates (2,4P-KTA and 2,6P-KTA), propofol-sterculia foetida mixed fatty acid conjugates (2,4P-STA and 2,6P-STA), propofol-eri pupal mixed fatty acid conjugates (2,4P-EFA and 2,6-EFA) and propofol-coconut mixed fatty acid conjugates (2,4P-CCFA and 2,6P-CCFA) were obtained by esterification of the fatty acid mixture to propofol isomers (2,4-diisopropylphenol and 2,6-diisopropylphenol). The prepared derivatives were characterized by FT-IR, NMR (1H, 13C) and GC–MS and were tested for in vitro antiproliferative studies on A549, MDA-MB-231, HeLa, Mia-Pa–Ca and HePG2 cancer cell lines. All the synthesized propofol-mixed fatty acid conjugates showed good to moderate specific growth inhibition of cancer cells on studied cell lines. The results suggest that all the novel propofol-mixed fatty acid conjugates possess antiproliferative properties that reduce the proliferation of cancer cells in vitro.

Pharmacognostical, Phytochemical and Anti-Arthritic Activity on the Bark of Sterculia Foetida Linn., and Isolation of Biological Marker

Abstract: AIM: To evaluate the Pharmacognostical, Phytochemical and Anti-arthritic activity on the bark of Sterculia foetida Linn., OBJECTIVE: Pharmacognostical studies: Establishment of Pharmacognostical standards for the bark of Sterculia foetida Linn., Phytochemical studies: To determine the phytochemical constituents and to isolate and identify the biomarkers present in the plant Pharmacological studies To select the active extract by in-vitro anti-arthritic and anti-oxidant studies To evaluate in-vivo anti-arthritic activity on the bark of Sterculia foetida Linn.,

Biodiesel Production from Sterculia foetida Oil by Using Solid Support Catalyst

Abstract: In the present work, the properties of bioester from Samrong oil (Sterculia Foetida) and characteristics of cellulose solid catalyst are described. Heterogeneous catalyst was prepared via carbonization, sulfonation and purification giving solid catalyst as brown powder. Control parameters were time and temperature of carbonization and sulfonation reaction, ratio of sulfuric acid to solid material and weight of solid material. The optimized carbonization condition was 300 °C for 15 h. The sulfonation temperature was 150 oC for 18 h under N2 producing 7.99 mmol/g of acid concentration on solid catalyst. The acidity in water of solid catalyst after purification and drying was decreasing. The results of biodiesel production showed that the triglyceride could be converted to biodiesel directly by one-step sulfonic acid catalyzed process. The experimental condition of reaction process was 3.0 M of catalyst concentration with 9:1 M ratio of methanol to triglyceride at the temperature of 80 °C. This catalysts provided high reactivity of transesterification. The present procedure represents a simple method for biodiesel production with a short reaction time and with moderate conversion rate.

Phytochemical Screening on the Successive Extracts of Bark of Sterculia Foetida Linn.

Abstract: Sterculia foetida is important medicinal plant having wide range of therapeutic values on different parts of the plant. The present study describes the phytochemical profile of the bark. The bark of Sterculia foetida is collected, dried, powdered and extracted using solvents such as n-hexane, chloroform, ethyl acetate and ethanol successively. Qualitative and quantitative phytochemical screenings of the extracts were carried out and it revealed the presence of chemical constituents like alkaloids, flavonoids, phenols, triterpenoids, tannins and steroids. HPLC and HPTLC analysis were carried out for the quantification of active constituents in the extracts.

Effect of sterculia foetida biodiesel on single cylinder four stroke diesel engine performance and emissions

Abstract: In the present work, transesterified new biodiesel of sterculia foetida oil is mixed with diesel and the engine performance, combustion and emission was analysed The primary objective work is to produce a new alternate and biodegradable fuel for compression ignition engine The biofuel oil is an extract from sterculia foetida seed and transesterfied with 20 % methanol and 2 % KOH The transesterfied biofuel concentrations were varied at 25%, 50%, 75% and 100% with diesel viz B25, B50, B75 and B100 The engine is operated at different load conditions with different concentration of fuel The experiments are conducted and the fuel blend B25 produces maximum of brake thermal efficiency in comparison with other biodiesel blends and produced maximum heat release and minimum emission produced at B25 biodiesel blend

Acute Toxicity And Anti-Arthritic Activity On The Bark Of Sterculia foetida Linn.,

Abstract: To investigate the anti-arthritic acitivity of ethanolic extract of Sterculia foetida Linn., on Wistar albino rats by Complete Freund’s Adjuvant model. The rats were selected and divided into five groups. Arthritis was induced to the animals in intra plantar region by using 0.1ml of Complete Freund’s Adjuvant and then treated for 211 days. The various parameters like changes in the body weight, haematological parameters, paw volume, radiographical and histopathology of bone were studied. The results were reported that arthritic control group showed significantly increased paw volume were as ethanolic extract of Sterculia foetida Linn., at the dose of 200mg/kg and 400mg /kg treated group showed significant reduction in the paw volume which is compared to the normal group and standard (Diclofenac sodium) treated group. Radio graphical and histopathological studies revealed that the anti-arthritic activity of bark of Sterculia foetida by preventing cartilage and bone destruction of the adjuvant induced arthritis rats. The study conclude that Sterculia foetida showed better anti-arthritic activity with significant decrease in paw volume, normalize the hematological, radio graphical and histopathological parameters.

Adsorption of Ni++ ions from aqueous solution onto microwave irradiated Sterculia foetida fruit shells

Abstract: Purpose – The purpose of this paper is to harness the potential of microwave pre-treatment to prepare carbon from locally available Sterculia foetida fruit shells for adsorption of heavy metals, particularly Nickel ions (Ni++), from effluent. Design/methodology/approach – The pre-treatment methods comprise conventional methods as sun drying and oven drying as well as high intensity microwave drying. Response surface methodology was employed to analyse the optimization of the process. The adsorption behavioural characteristics of the material were established applying adsorption isotherms. Findings – Adsorption of Ni++ was found to be effective in microwave drying at output power of 300 W. It was observed that the maximum adsorption capacity was attained at pH 6; an adsorbent dosage of 0.25 mgml−1 and initial metal ion concentration of 20 ppm with an interactive effect of initial concentration and dosage. Originality/value – The research puts emphasise on prospecting of novel biomass for carbonization and ...

DEVELOPMENT AND EVALUATION OF OFLOXACIN FLOATING TABLETS USING NATURAL POLYMER: STERCULIA FOETIDA LINN. GUM Original Article

Abstract: Objective: The aim of the present work was to develop a gastro retentive drug delivery system of Ofloxacin with the objective of retarding the drug release when the dosage form is exposed to gastrointestinal fluid. Methods: Floating tablets of Ofloxacin were developed using a natural gum like Sterculia foetida. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in vitro buoyancy, in vitro drug release and release order kinetics. The formulations were optimized for different concentrations of Sterculia foetida. Results: The results of in vitro release studies showed that optimized formulation (F4) could sustain drug release (97.86%) for 24 h and remain buoyant for 24 h. The optimized formulation was subjected to various release kinetic investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation. Conclusion: Floating tablets of Ofloxacin were successfully formulated with the ability of providing controlled release and non-Fickian transport of the drug from tablets was confirmed.