T
Timothy M. Carlos
Researcher at University of Pittsburgh
Publications - 43
Citations - 6824
Timothy M. Carlos is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Traumatic brain injury & Cell adhesion molecule. The author has an hindex of 30, co-authored 43 publications receiving 6628 citations.
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Journal ArticleDOI
Leukocyte-endothelial adhesion molecules.
Timothy M. Carlos,John M. Harlan +1 more
TL;DR: Investigations have progressed from the early descriptions by intravital microscopy and histology, to functional and immunologic characterization of adhesion molecules, and now to the development of genetically deficient animals and the first phase I trial of "anti-adhesion" therapy in humans.
Journal ArticleDOI
Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia: Risks and Benefits Up to 9 Years of Treatment
Martin H. Steinberg,Martin H. Steinberg,Franca B. Barton,Oswaldo Castro,Charles H. Pegelow,Samir K. Ballas,Abdullah Kutlar,Eugene P. Orringer,Rita Bellevue,Nancy F. Olivieri,James R. Eckman,Mala Varma,G. Ramirez,Brian Adler,Wally R. Smith,Timothy M. Carlos,Kenneth I. Ataga,Laura DeCastro,Carolyn Bigelow,Yogen Saunthararajah,Margaret Telfer,Elliott Vichinsky,Susan Claster,Susan Shurin,Kenneth Bridges,Myron A. Waclawiw,Duane Bonds,Michael L. Terrin +27 more
TL;DR: In a long-term observational follow-up study of mortality in patients with SCA who originally participated in the randomized, double-blind, placebo-controlled Multicenter Study of Hydroxyurea in Patients with Sickle Cell Anemia (MSH), conducted in 1992-1995, to determine whether hydroxyuraxurea attenuates mortality in Patients With SCA as discussed by the authors.
Journal ArticleDOI
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up
Martin H. Steinberg,William F. McCarthy,Oswaldo Castro,Samir K. Ballas,F. Danny Armstrong,Wally R. Smith,Kenneth I. Ataga,Paul Swerdlow,Abdullah Kutlar,Laura DeCastro,Myron A. Waclawiw,Eugene P. Orringer,Susan Jones,D. Strayhorn,Wendell F. Rosse,George Phillips,D. Peace,A. Johnson-Telfair,Lisa Daitch,Paul F. Milner,A. Tracy,S. Valdez,G. E. Allen,J. Moshang,B. Scott,Carolyn Bigelow,A. Anderson,V. Sabahi,T. Harrington,W. Labrousse,Charles H. Pegelow,D. Temple,E. Case,R. Harrell,S. Childerie,Stephen H. Embury,B. Schmidt,D. Davies,Yogen Saunthararajah,Mabel Koshy,N. Talischy-Zahed,L. Dorn,G. Pendarvis,M. McGee,Margaret Telfer,A. Davis,O. C. Onyekwere,C. Nwokolo,Helga Finke,Elliott Perlin,J. Siteman,M. Bryan,T. Saunders,Y. Barber,P. Gascon,P. Di Paolo,S. Gargiulo,James R. Eckman,E. Carter-Randall,J. H. Bailey,A. Platt,L. Waller,G. Ramirez,V. Knors,S. Hernandez,E. M. Rodriguez,E. Wilkes,Elliott Vichinsky,Ward Hagar,C. Hoehner,E. Hackney-Stevens,S. Claster,A. Earles,K. Kleman,K. McLaughlin,L. White,B. Maddox,L. Usry,A. Brenner,K. Williams,R. O'Brien,K. Genther,Susan B. Shurin,Brian W. Berman,K. Chiarucci,L. Keverline,Nancy F. Olivieri,J. Chow,M. Hui,D. Shaw,N. Lewis,Maureen Okam,Elyse Mandell,A. Palmer,Kenneth Bridges,B. Tynan,C. Winograd,Rita Bellevue,Harvey Dosik,M. Sheikhai,P. Ryans,H. Souffrant,Brian Adler,L. Eskridge,Josef T. Prchal,J. Braddock,T. McArdle,Timothy M. Carlos,A. Roundtree-Schmotzer,D. Gardner +109 more
TL;DR: It is suggested that long‐term use of hydroxyurea is safe and might decrease mortality, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment.
Journal ArticleDOI
Surgically Induced Leukocytic Infiltrates Within the Rat Intestinal Muscularis Mediate Postoperative Ileus
Jörg C. Kalff,Timothy M. Carlos,Wolfgang H. Schraut,Timothy R. Billiar,Richard L. Simmons,Anthony J. Bauer +5 more
TL;DR: It is demonstrated that adhesion molecule antibodies prevent surgically induced suppression of intestinal muscle contractions and therefore suggests that late postoperative ileus is mediated through a leukocytic inflammatory response within the intestinal muscularis externa.
Journal ArticleDOI
Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats.
Timothy M. Carlos,Robert S. B. Clark,D. Franicola-Higgins,Joanne K. Schiding,Patrick M. Kochanek +4 more
TL;DR: Leukoc et al. as mentioned in this paper found that up-regulation and prolonged expression of ICAM-1 (CD54) on endothelium in the traumatized hemisphere (P < 0.05 at 4, 24, 48, and 72 h post-trauma) and increased expression of CD54 on blood vessels in the contralateral, non-traumatized hemisphere 48 h posurauma.