A
A M Smits
Researcher at Leiden University
Publications - 7
Citations - 7258
A M Smits is an academic researcher from Leiden University. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 6, co-authored 7 publications receiving 7017 citations.
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Journal ArticleDOI
Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
Journal ArticleDOI
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Vincent T.H.B.M. Smit,Angelina J.M. Boot,A M Smits,Gert Jan Fleuren,Cees J. Cornelisse,Johannes L. Bos +5 more
TL;DR: DNAs from human pancreatic adenocarcinomas were analyzed for the presence of mutations in codons 12, 13 and 61 of the NRAS, KRAS and HRAS gene and found a mutation in codon 12 of the KRAS gene, confirming the findings of Almoguera et al.
Journal ArticleDOI
A novel function of the transforming domain of E1a: repression of AP-1 activity.
Rienk Offringa,Stephan Gebel,Hans van Dam,Marc Timmers,A M Smits,Ronald Zwart,Bernd Stein,Johannes L. Bos,Alex J. van der Eb,Peter Herrlich +9 more
TL;DR: This repression depends on conserved region 1, one of the transforming domains of E1a, indicating that it is an integral feature of adenovirus transformation, and is a unique property among dominant oncogenes.
Journal ArticleDOI
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
H. Van Dam,Rienk Offringa,Ingeborg Meijer,B Stein,A M Smits,P Herrlich,Johannes L. Bos,A. J. Van Der Eb +7 more
TL;DR: The fact that E1A-induced alterations in the repertoire of AP-1 transcription factors depend on its transforming domain in conserved region 1 suggests that the effects are relevant for the transformation process.
Journal ArticleDOI
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin
TL;DR: Although the sml gene is strongly suppressed in AdE1A-transformed cells, treatment with growth factors or transfection of EJras still causes a raise in sml mRNA levels, indicating that E1A does not block the induction mechanism itself.