A
A MacNeil
Researcher at University College London
Publications - 12
Citations - 1939
A MacNeil is an academic researcher from University College London. The author has contributed to research in topics: Retina & Progenitor cell. The author has an hindex of 9, co-authored 12 publications receiving 1839 citations.
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Journal ArticleDOI
Retinal Repair by Transplantation of Photoreceptor Precursors
Robert E MacLaren,Rachael A. Pearson,A MacNeil,Ronald H. Douglas,Thomas E. Salt,Masayuki Akimoto,Anand Swaroop,Jane C. Sowden,Robin R. Ali +8 more
TL;DR: It is shown that donor cells can integrate into the adult or degenerating retina if they are taken from the developing retina at a time coincident with the peak of rod genesis, and the ontogenetic stage of donor cells for successful rod photoreceptor transplantation is defined.
Journal ArticleDOI
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
Journal ArticleDOI
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration.
F C Schlichtenbrede,A MacNeil,James W.B. Bainbridge,M Tschernutter,Adrian J. Thrasher,Andrew Smith,Robin R. Ali +6 more
TL;DR: It is demonstrated that intraocular CNTF gene delivery may have a deleterious effect on the retina and caution against its application in clinical trials.
Journal ArticleDOI
In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration
Prateek K. Buch,Robert E MacLaren,Yanai Duran,Kamaljit S. Balaggan,A MacNeil,F C Schlichtenbrede,Alexander J. Smith,Robin R. Ali +7 more
TL;DR: AAV-mediated delivery of Gdnf to slow cell death in two rodent models of retinitis pigmentosa and to enhance retinal function in combination with the relevant gene replacement therapy are demonstrated.
Journal ArticleDOI
Comparative Analysis of Progenitor Cells Isolated from the Iris, Pars Plana, and Ciliary Body of the Adult Porcine Eye
A MacNeil,Rachael A. Pearson,Robert E MacLaren,Robert E MacLaren,Alexander J. Smith,Jane C. Sowden,Robin R. Ali +6 more
TL;DR: It is suggested that a population of cells derived from the adult iris, pars plana, and ciliary body of a large mammalian species, the pig, has progenitor properties and neurogenic potential, thereby providing novel sources of donor cells for transplantation studies.